Welcome to the De Tomaso Lab!

Our lab works at the intersection of immunology, stem cell biology and regeneration using the marine basal chordate, Botryllus schlosseri as a model. Unique biological features of Botryllus, including a natural transplantation reaction, parasitic stem cells, and a colonial life history that includes regeneration of all somatic and germline tissues on a weekly basis, allow novel approaches for studies in each of these fields. In turn, results from those studies have allowed us to explore new fields, including angiogenesis, mechanotransduction and aging. Botryllus has a wealth of biology ripe for experimentation, and our overall goal is to utilize these unique features and carry out innovative, interdisciplinary research. Please follow the links above to learn more about our model organism, our current research, and who we are as a lab.