Phone: (805) 893-7276
Office: 1107 Life Sciences Building
Characterization of the mechanisms underlying age-related functional and morphological changes in the vasculature of the invertebrate chordate Botryllus schlosseri.
Elucidating the molecular mechanisms behind stem cell competition in Botryllus schlosseri to gain insight into the processes of development and creation of a cancerized field.
My work focuses on injury-induced regeneration in two marine invertebrates, Botryllus schlosseri and Botrylloides diagensis. I've discovered that these closely related tunicate species have disparate mechanisms for injury recovery: one depends on ectopic tissue development and the other on blood borne stem cells. Currently looking into the stem-cell mediated process to temporaily quantify conserved molecular pathways, including Wnt and Notch, during the healing response. My overall aim is to understand how cell-to-cell signaling is used to coordinate early regeneration niche formation.
Explore the trade offs that dictate life history strategies under varying environmental conditions and how they underlie the molecular mechanisms that affect regeneration and aging.
I am interested in investigating the molecular mechanisms underlying self/non-self recognition in Botryllus schlosseri utilizing tissue culture models to recombinant proteins.