The sea urchin kinome: a first look.

TitleThe sea urchin kinome: a first look.
Publication TypeJournal Article
Year of Publication2006
AuthorsBradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Genevière A-M, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, Manning G
JournalDev Biol
Volume300
Issue1
Pagination180-93
Date Published2006 Dec 1
ISSN0012-1606
KeywordsAnimals, Embryo, Nonmammalian, Gene Expression Regulation, Developmental, Phosphorylation, Phylogeny, Protein Kinases, Sea Urchins, Signal Transduction
Abstract

This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism.

DOI10.1016/j.ydbio.2006.08.074
Alternate JournalDev. Biol.
PubMed ID17027740
Grant List61464 / / PHS HHS / United States
HD14483 / HD / NICHD NIH HHS / United States
P30 CA014195 / CA / NCI NIH HHS / United States
R01 HG004164-01 / HG / NHGRI NIH HHS / United States