Signal transduction at fertilization: the Ca2+ release pathway in echinoderms and other invertebrate deuterostomes.

TitleSignal transduction at fertilization: the Ca2+ release pathway in echinoderms and other invertebrate deuterostomes.
Publication TypeJournal Article
Year of Publication2006
AuthorsTownley IK, Roux MM, Foltz KR
JournalSemin Cell Dev Biol
Volume17
Issue2
Pagination293-302
Date Published2006 Apr
ISSN1084-9521
KeywordsAnimals, Calcium Signaling, Echinodermata, Endoplasmic Reticulum, Inositol 1,4,5-Trisphosphate, Ovum, Phospholipase C gamma, Sperm-Ovum Interactions, src-Family Kinases
Abstract

Gamete interaction and fusion triggers a number of events that lead to egg activation and development of a new organism. A key event at fertilization is the rise in intracellular calcium. In deuterostomes, this calcium is released from the egg's endoplasmic reticulum and is necessary for proper activation. This article reviews recent data regarding how gamete interaction triggers the initial calcium release, focusing on the echinoderms (invertebrate deuterostomes) as model systems. In eggs of these animals, Src-type kinases and phospholipase C-gamma are required components of the initial calcium trigger pathway in eggs.

DOI10.1016/j.semcdb.2006.02.006
Alternate JournalSemin. Cell Dev. Biol.
PubMed ID16545968