Ca2+ signalling during fertilization of echinoderm eggs.

TitleCa2+ signalling during fertilization of echinoderm eggs.
Publication TypeJournal Article
Year of Publication2001
AuthorsJaffe LA, Giusti AF, Carroll DJ, Foltz KR
JournalSemin Cell Dev Biol
Date Published2001 Feb
KeywordsAnimals, Calcium Signaling, Echinodermata, Fertilization, Ovum

The Ca2+ rise at fertilization of echinoderm eggs is initiated by a process requiring the sequential activation of a Src family kinase, phospholipase C gamma, and the inositol trisphosphate receptor/channel in the endoplasmic reticulum. The consequences of the Ca2+ rise include exocytosis of cortical granules, which establishes a block to polyspermy, and inactivation of MAP kinase, which functions in linking the Ca2+ rise to the reinitiation of the cell cycle.

Alternate JournalSemin. Cell Dev. Biol.
PubMed ID11162746