Ca2+ signalling during fertilization of echinoderm eggs.

TitleCa2+ signalling during fertilization of echinoderm eggs.
Publication TypeJournal Article
Year of Publication2001
AuthorsJaffe LA, Giusti AF, Carroll DJ, Foltz KR
JournalSemin Cell Dev Biol
Volume12
Issue1
Pagination45-51
Date Published2001 Feb
ISSN1084-9521
KeywordsAnimals, Calcium Signaling, Echinodermata, Fertilization, Ovum
Abstract

The Ca2+ rise at fertilization of echinoderm eggs is initiated by a process requiring the sequential activation of a Src family kinase, phospholipase C gamma, and the inositol trisphosphate receptor/channel in the endoplasmic reticulum. The consequences of the Ca2+ rise include exocytosis of cortical granules, which establishes a block to polyspermy, and inactivation of MAP kinase, which functions in linking the Ca2+ rise to the reinitiation of the cell cycle.

DOI10.1006/scdb.2000.0216
Alternate JournalSemin. Cell Dev. Biol.
PubMed ID11162746