Gamete and immune cell recognition revisited.

TitleGamete and immune cell recognition revisited.
Publication TypeJournal Article
Year of Publication1995
AuthorsBelton RJ, Foltz KR
JournalBioessays
Volume17
Issue12
Pagination1075-80
Date Published1995 Dec
ISSN0265-9247
KeywordsAnimals, Antigen-Presenting Cells, Female, Lymphocyte Activation, Male, Sperm-Ovum Interactions, T-Lymphocytes
Abstract

Fertilization is the result of a series of successful recognition and binding events mediated by gamete surface molecules. Recent advances in the identification and characterization of some of these recognition molecules provide extremely valuable information necessary to understand sperm-egg recognition and subsequent egg activation. We discuss these new data in the context of the model of gamete recognition first proposed by F.R. Lillie in the early part of the 20th century, and revisited periodically in the subsequent literature, which relates fertilization events to those of immune cell recognition and activation events. Here we discuss the principles underlying the molecular recognition and activation mechanisms of gametes and immune cells.

DOI10.1002/bies.950171212
Alternate JournalBioessays
PubMed ID8634069
Grant ListR01 HD30698 / HD / NICHD NIH HHS / United States