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MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.

TitleMCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.
Publication TypeJournal Article
Year of Publication2016
AuthorsBettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH
JournalAlzheimers Dement (Amst)
Volume3
Pagination91-7
Date Published2016
Abstract

INTRODUCTION: MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.

METHODS: MCP-1 and eotaxin-1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained.

RESULTS: An interaction was noted between MCP-1 and eotaxin-1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non-chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains.

DISCUSSION: These results suggest a potentially selective role for MCP-1 and eotaxin-1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.

DOI10.1016/j.dadm.2016.05.004
Alternate JournalAlzheimers Dement (Amst)
PubMed ID27453930
PubMed Central IDPMC4941041
Grant ListP50 AG023501 / AG / NIA NIH HHS / United States
R01 AG048234 / AG / NIA NIH HHS / United States
K23 AG042492 / AG / NIA NIH HHS / United States
R01 AG032289 / AG / NIA NIH HHS / United States
R01 AG045611 / AG / NIA NIH HHS / United States