Dai, Guo et al, Science, in press
Cell motility is essential for embryonic development, adult homeostasis, tumor cell
dissemination, and immunity. Migrating cells navigate physical features of their
microenvironment, however the in vivo significance of tissue topography for pathfinding is
mostly unknown. Dai, Guo et al. use Drosophila border cells to study path selection in vivo.
Experiments, mathematical modeling and simulations show that tissue microtopography