Q&A: Cellular near death experiences-what is anastasis?

TitleQ&A: Cellular near death experiences-what is anastasis?
Publication TypeJournal Article
Year of Publication2017
AuthorsSun G, Montell DJ
JournalBMC Biol
Volume15
Issue1
Pagination92
Date Published2017 10 24
ISSN1741-7007
KeywordsApoptosis, Cell Physiological Phenomena, Cells
Abstract

<p>Apoptosis is a form of programmed cell death that is carried out by proteolytic enzymes called caspases. Executioner caspase activity causes cells to shrink, bleb, and disintegrate into apoptotic bodies and has been considered a point of no return for apoptotic cells. However, relatively recent work has shown that cells can survive transient apoptotic stimuli, even after executioner caspase activation. This process is called anastasis. In this Q&A, we answer common questions that arise regarding anastasis, including how it is defined, the origin of the name, the potential physiological consequences, molecular mechanisms, and open questions for this new field of study.</p>

DOI10.1186/s12915-017-0441-z
Alternate JournalBMC Biol.
PubMed ID29065871
PubMed Central IDPMC5655817
Grant ListDP1 CA195760 / CA / NCI NIH HHS / United States