|Title||Cell interactions in collective cell migration|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Mishra AK, Campanale JP, Mondo JA, Montell DJ|
|Keywords||Cell migration, Chemotaxis, Contact activation of locomotion, Contact inhibition, Heterotypic cell adhesion, Homotypic cell adhesion, Metastasis|
Collective cell migration is the coordinated movement of a physically connected group of cells and is a prominent driver of development and metastasis. Interactions between cells within migrating collectives, and between migrating cells and other cells in the environment, play key roles in stimulating motility, steering and sometimes promoting cell survival. Similarly, diverse heterotypic interactions and collective behaviors likely contribute to tumor metastasis. Here, we describe a sampling of cells that migrate collectively , including well-established and newer examples. We focus on the under-appreciated property that many - perhaps most - collectively migrating cells move as cooperating groups of distinct cell types.