Tissue topography steers migrating border cells.

TitleTissue topography steers migrating border cells.
Publication TypeJournal Article
Year of Publication2020
AuthorsDai W, Guo X, Cao Y, Mondo JA, Campanale JP, Montell BJ, Burrous H, Streichan S, Gov N, Rappel W-J, Montell DJ
JournalScience
Volume370
Issue6519
Pagination987-990
Date Published2020 Nov 20
ISSN1095-9203
Abstract

Moving cells can sense and respond to physical features of the microenvironment; however, in vivo, the significance of tissue topography is mostly unknown. Here, we used border cells, an established model for in vivo cell migration, to study how chemical and physical information influences path selection. Although chemical cues were thought to be sufficient, live imaging, genetics, modeling, and simulations show that microtopography is also important. Chemoattractants promote predominantly posterior movement, whereas tissue architecture presents orthogonal information, a path of least resistance concentrated near the center of the egg chamber. E-cadherin supplies a permissive haptotactic cue. Our results provide insight into how cells integrate and prioritize topographical, adhesive, and chemoattractant cues to choose one path among many.

DOI10.1126/science.aaz4741
Alternate JournalScience
PubMed ID33214282