Group choreography: mechanisms orchestrating the collective movement of border cells.

TitleGroup choreography: mechanisms orchestrating the collective movement of border cells.
Publication TypeJournal Article
Year of Publication2012
AuthorsMontell DJ, Yoon WHee, Starz-Gaiano M
JournalNat Rev Mol Cell Biol
Volume13
Issue10
Pagination631-45
Date Published2012 Oct
ISSN1471-0080
KeywordsAnimals, Cell Movement, Drosophila melanogaster, Drosophila Proteins, Female, Ovarian Follicle, STAT Transcription Factors
Abstract

<p>Cell movements are essential for animal development and homeostasis but also contribute to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to the substrate, contract and detach at the rear. It is less clear how cells that migrate in interconnected groups in vivo coordinate their behaviour and navigate through natural environments. The border cells of the Drosophila melanogaster ovary have emerged as an excellent model for the study of collective cell movement, aided by innovative genetic, live imaging, and photomanipulation techniques. Here we provide an overview of the molecular choreography of border cells and its more general implications.</p>

DOI10.1038/nrm3433
Alternate JournalNat. Rev. Mol. Cell Biol.
PubMed ID23000794
PubMed Central IDPMC4099007
Grant ListR01 GM046425 / GM / NIGMS NIH HHS / United States
R01 GM073164 / GM / NIGMS NIH HHS / United States
R01GM46425 / GM / NIGMS NIH HHS / United States
R01GM73164 / GM / NIGMS NIH HHS / United States