Morphogenetic cell movements: diversity from modular mechanical properties.

TitleMorphogenetic cell movements: diversity from modular mechanical properties.
Publication TypeJournal Article
Year of Publication2008
AuthorsMontell DJ
JournalScience
Volume322
Issue5907
Pagination1502-5
Date Published2008 Dec 05
ISSN1095-9203
KeywordsAnimals, Cell Adhesion, Cell Movement, Cell Physiological Phenomena, Cell Polarity, Cell Shape, Cell Surface Extensions, Embryonic Development, Extracellular Matrix, Models, Biological, Morphogenesis, Organogenesis
Abstract

<p>Animal tissue and organ development requires the orchestration of cell movements, including those of interconnected cell groups, termed collective cell movements. Such movements are incredibly diverse. Recent work suggests that two core cellular properties, cell-cell adhesion and contractility, can largely determine geometry, packing, sorting, and rearrangement of epithelial cell layers. Two additional force-generating properties, the ability to generate cell protrusions and cell adhesion to the extracellular matrix, contribute to active motility. These mechanical properties can be regulated independently in cells, suggesting that they can be employed in a combinatorial manner. A small number of properties used in combination could, in principle, generate a diverse array of cell shapes and arrangements and thus orchestrate the varied morphogenetic events observed during metazoan organ development.</p>

DOI10.1126/science.1164073
Alternate JournalScience
PubMed ID19056976
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States
R01 GM046425 / GM / NIGMS NIH HHS / United States
U54 GM064346 / GM / NIGMS NIH HHS / United States
R01GM73164 / GM / NIGMS NIH HHS / United States