Modeling migration and metastasis in Drosophila.

TitleModeling migration and metastasis in Drosophila.
Publication TypeJournal Article
Year of Publication2007
AuthorsJang AC-C, Starz-Gaiano M, Montell DJ
JournalJ Mammary Gland Biol Neoplasia
Volume12
Issue2-3
Pagination103-14
Date Published2007 Sep
ISSN1083-3021
KeywordsAnimals, Cadherins, Cell Movement, Drosophila melanogaster, Humans, Models, Biological, Neoplasm Metastasis, Signal Transduction
Abstract

<p>Cell motility makes essential contributions to normal embryonic development and homeostasis. It is also thought to contribute in important ways to tumor metastasis. Because of this dual importance, cell migration has been extensively studied. The fruit fly Drosophila melanogaster has served as an important model organism for genetic analysis of many aspects of developmental biology, including cell migration. Here we describe the various types of cell movements that have been studied in detail, which represent models for epithelial-to-mesenchymal transition, transepithelial migration, inflammation, wound healing and invasion. We summarize what has been learned about the molecular control of cell migration from genetic studies in the fly. In addition, we describe recent efforts to model tumor metastasis directly in Drosophila by expressing oncogenes and/or mutating tumor suppressor genes. Together these studies suggest that Drosophila has much to offer as a model for varied aspects of tumor metastasis.</p>

DOI10.1007/s10911-007-9042-8
Alternate JournalJ Mammary Gland Biol Neoplasia
PubMed ID17549611
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States