A kinase gets caspases into shape.

TitleA kinase gets caspases into shape.
Publication TypeJournal Article
Year of Publication2006
AuthorsMontell DJ
JournalCell
Volume126
Issue3
Pagination450-2
Date Published2006 Aug 11
ISSN0092-8674
KeywordsActin Cytoskeleton, Animals, Apoptosis, Caspases, Cell Differentiation, Cell Shape, Drosophila melanogaster, Drosophila Proteins, Inhibitor of Apoptosis Proteins, Phosphotransferases, Sense Organs
Abstract

<p>Two new papers (Kuranaga et al., 2006; Oshima et al., 2006) describe a previously uncharacterized Drosophila kinase (DmIKK epsilon) that regulates the abundance of DIAP1, a protein best known for its ability to inhibit apoptosis. However, DmIKK epsilon-mediated degradation of DIAP1 does not regulate apoptosis as might be predicted but instead regulates actin dynamics, cell morphology, and the differentiation of sensory organ precursor cells.</p>

DOI10.1016/j.cell.2006.07.017
Alternate JournalCell
PubMed ID16901779
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States