The social lives of migrating cells in Drosophila.

TitleThe social lives of migrating cells in Drosophila.
Publication TypeJournal Article
Year of Publication2006
AuthorsMontell DJ
JournalCurr Opin Genet Dev
Volume16
Issue4
Pagination374-83
Date Published2006 Aug
ISSN0959-437X
KeywordsAnimals, Cell Movement, Cell Survival, Drosophila, Drosophila Proteins, Germ Cells, Hemocytes, Lipids, Membrane Proteins, Mesoderm, Phosphatidate Phosphatase, Salivary Glands
Abstract

<p>Studies of cell migration in Drosophila are yielding insights into the complex interactions migrating cells have with each other and with the cells in their environment. Intriguing links between factors that promote cell migration and those that control cell survival have been reported recently. For example, migrating germ cells compete with the surrounding somatic tissue for the substrate of the lipid phosphate phosphatases encoded by the genes Wunen and Wunen2. Germ cells take up the dephosphorylated lipid and require it for their survival. In addition, the secreted growth factors called PVFs, previously thought to guide the migrations of hemocytes in the embryo, were found to function instead predominantly as survival factors. And in border cells, DIAP1 and Dronc, two proteins known mainly for their ability to regulate cell death, were found to control cell migration.</p>

DOI10.1016/j.gde.2006.06.010
Alternate JournalCurr Opin Genet Dev
PubMed ID16797177
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States