Anchors away! Fos fosters anchor-cell invasion.

TitleAnchors away! Fos fosters anchor-cell invasion.
Publication TypeJournal Article
Year of Publication2005
AuthorsMontell DJ
JournalCell
Volume121
Issue6
Pagination816-7
Date Published2005 Jun 17
ISSN0092-8674
KeywordsAnimals, Basement Membrane, Caenorhabditis elegans, Cell Movement, Gene Expression Regulation, Neoplasm Invasiveness, Proto-Oncogene Proteins c-fos
Abstract

<p>Invasion of cells through breakdown of the basement membrane is a crucial step during development and cancer metastasis. In this issue of Cell, simple and genetically tractable cellular assay in the worm for elucidating the molecular processes that underlie cell invasion in vivo is described. They demonstrate that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes (encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin).</p>

DOI10.1016/j.cell.2005.06.003
Alternate JournalCell
PubMed ID15960969
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States