Ovarian cancer metastasis: integrating insights from disparate model organisms.

TitleOvarian cancer metastasis: integrating insights from disparate model organisms.
Publication TypeJournal Article
Year of Publication2005
AuthorsNaora H, Montell DJ
JournalNat Rev Cancer
Volume5
Issue5
Pagination355-66
Date Published2005 May
ISSN1474-175X
KeywordsAnimals, Ascites, Cadherins, Cell Adhesion, Cell Movement, Drosophila melanogaster, Female, Growth Substances, Models, Animal, Neoplasm Metastasis, Ovarian Neoplasms, Ovary, Signal Transduction
Abstract

<p>Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets.</p>

DOI10.1038/nrc1611
Alternate JournalNat. Rev. Cancer
PubMed ID15864277
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States