Ovarian cancer metastasis: integrating insights from disparate model organisms.

TitleOvarian cancer metastasis: integrating insights from disparate model organisms.
Publication TypeJournal Article
Year of Publication2005
AuthorsNaora H, Montell DJ
JournalNat Rev Cancer
Date Published2005 May
KeywordsAnimals, Ascites, Cadherins, Cell Adhesion, Cell Movement, Drosophila melanogaster, Female, Growth Substances, Models, Animal, Neoplasm Metastasis, Ovarian Neoplasms, Ovary, Signal Transduction

<p>Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets.</p>

Alternate JournalNat Rev Cancer
PubMed ID15864277
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States