Genes that drive invasion and migration in Drosophila.

TitleGenes that drive invasion and migration in Drosophila.
Publication TypeJournal Article
Year of Publication2004
AuthorsStarz-Gaiano M, Montell DJ
JournalCurr Opin Genet Dev
Date Published2004 Feb
KeywordsAnimals, Cell Adhesion, Cell Movement, Cytoskeleton, Drosophila, Receptor Protein-Tyrosine Kinases

<p>Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.</p>

Alternate JournalCurr Opin Genet Dev
PubMed ID15108810
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States