A new trick for Cyclin-Cdk: activation of STAT.

TitleA new trick for Cyclin-Cdk: activation of STAT.
Publication TypeJournal Article
Year of Publication2003
AuthorsSilver DL, Montell DJ
JournalDev Cell
Volume4
Issue2
Pagination148-9
Date Published2003 Feb
ISSN1534-5807
KeywordsAnimals, Cell Cycle, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, DNA-Binding Proteins, Drosophila melanogaster, Drosophila Proteins, Female, Proto-Oncogene Proteins, Signal Transduction, Transcription Factors
Abstract

<p>New work in Drosophila demonstrates that cdk4 loss causes phenotypes similar to the loss of JAK/STAT pathway components. Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation.</p>

DOI10.1016/s1534-5807(03)00028-5
Alternate JournalDev. Cell
PubMed ID12586057
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States