Border-cell migration: the race is on.

TitleBorder-cell migration: the race is on.
Publication TypeJournal Article
Year of Publication2003
AuthorsMontell DJ
JournalNat Rev Mol Cell Biol
Date Published2003 Jan
KeywordsAnimals, Cell Movement, Drosophila melanogaster, Epithelial Cells, Female, Gene Expression Regulation, Developmental, Ovary, Signal Transduction

<p>The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.</p>

Alternate JournalNat Rev Mol Cell Biol
PubMed ID12511865
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States