Border-cell migration: the race is on.

TitleBorder-cell migration: the race is on.
Publication TypeJournal Article
Year of Publication2003
AuthorsMontell DJ
JournalNat Rev Mol Cell Biol
Volume4
Issue1
Pagination13-24
Date Published2003 Jan
ISSN1471-0072
KeywordsAnimals, Cell Movement, Drosophila melanogaster, Epithelial Cells, Female, Gene Expression Regulation, Developmental, Ovary, Signal Transduction
Abstract

<p>The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.</p>

DOI10.1038/nrm1006
Alternate JournalNat. Rev. Mol. Cell Biol.
PubMed ID12511865
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States