Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.

TitleParacrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.
Publication TypeJournal Article
Year of Publication2001
AuthorsSilver DL, Montell DJ
JournalCell
Volume107
Issue7
Pagination831-41
Date Published2001 Dec 28
ISSN0092-8674
KeywordsAnimals, Cell Movement, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Epithelial Cells, Female, Humans, Mutation, Ovary, Paracrine Communication, Protein-Tyrosine Kinases, Signal Transduction, STAT Transcription Factors, Trans-Activators
Abstract

<p>The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive cells. The ligand for this pathway, Unpaired (UPD), is expressed by two central cells within the migratory cell cluster. Mutations in upd or jak cause defects in migration and a reduction in the number of cells recruited to the cluster. Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive.</p>

DOI10.1016/s0092-8674(01)00607-9
Alternate JournalCell
PubMed ID11779460
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States
GM 46425 / GM / NIGMS NIH HHS / United States