Developmental regulation of cell migration. Insight from a genetic approach in Drosophila.

TitleDevelopmental regulation of cell migration. Insight from a genetic approach in Drosophila.
Publication TypeJournal Article
Year of Publication1999
AuthorsMontell DJ
JournalCell Biochem Biophys
Date Published1999
KeywordsAnimals, CCAAT-Enhancer-Binding Proteins, Cell Movement, DNA-Binding Proteins, Drosophila, Female, Myosins, Nuclear Proteins, Ovary, Ovum, Receptor Protein-Tyrosine Kinases, Transcription Factors

<p>Cell movements are fascinating and dramatic features of normal animal development. Moreover, failures in cell migration can lead to birth defects, and inappropriate cell migration can lead to cancer metastasis. Genetic approaches are beginning to provide some insights into the molecular basis for the developmental regulation of cell migration. This review discusses the progress that has been made in understanding the regulation of cell migration during Drosophila development, using a molecular genetic approach. In particular, these studies have implicated signaling through a receptor tyrosine kinase in the spatial control of migration. Reorganization of the cytoskeleton, under the control of the guanosine triphosphatase, Rac, is also critical for cell migration. Finally, genetic studies have demonstrated that the timing of cell migration is under transcriptional control.</p>

Alternate JournalCell Biochem Biophys
PubMed ID10736748
Grant ListR01 AG063907 / AG / NIA NIH HHS / United States