Drosophila laminin: sequence of B2 subunit and expression of all three subunits during embryogenesis.

TitleDrosophila laminin: sequence of B2 subunit and expression of all three subunits during embryogenesis.
Publication TypeJournal Article
Year of Publication1989
AuthorsMontell DJ, Goodman CS
JournalJ Cell Biol
Volume109
Issue5
Pagination2441-53
Date Published1989 Nov
ISSN0021-9525
KeywordsAmino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Drosophila, Embryo, Nonmammalian, Gene Expression, Genes, Laminin, Macromolecular Substances, Mice, Molecular Sequence Data, Nucleic Acid Hybridization, Sequence Homology, Nucleic Acid, Species Specificity
Abstract

<p>In a previous study, we described the cloning of the genes encoding the three subunits of Drosophila laminin, a substrate adhesion molecule, and the cDNA sequence of the B1 subunit (Montell and Goodman, 1988). This analysis revealed the similarity of Drosophila laminin with the mouse and human complexes in subunit composition, domain structure, and amino acid sequence. In this paper, we report the deduced amino acid sequence of the B2 subunit. We then describe the expression and tissue distribution of the three subunits of laminin during Drosophila embryogenesis using both in situ hybridization and immunolocalization techniques, with particular emphasis on its expression in and around the developing nervous system.</p>

DOI10.1083/jcb.109.5.2441
Alternate JournalJ. Cell Biol.
PubMed ID2808533
PubMed Central IDPMC2115843
Grant ListNS18366 / NS / NINDS NIH HHS / United States