Diverse and dynamic sources and sinks in gradient formation and directed migration.

TitleDiverse and dynamic sources and sinks in gradient formation and directed migration.
Publication TypeJournal Article
Year of Publication2014
AuthorsCai D, Montell DJ
JournalCurr Opin Cell Biol
Volume30
Pagination91-8
Date Published2014 Oct
ISSN1879-0410
KeywordsAnimals, Cell Communication, Cell Movement, Cell Polarity, Chemotactic Factors, Humans
Abstract

<p>The traditional view of directional cell migration within a tissue is that it requires a gradient of a soluble attractive chemical that is stable in space and time due to the presence of a source and a sink. However, advances in live imaging technology and the ability to study cell migration in vivo have revealed that endogenous sources and sinks are typically far more varied and complex. Both sources and sinks can be made up of multiple tissues. During long-range migrations, cells tend to divide up their trajectories and follow different source signals in each segment. When a single source signal is used repeatedly in each segment, its expression is dynamically controlled. Source signals can also originate locally from neighboring migrating cells. Sinks are important in some cases but not all, to sculpt a permissive migratory path or allow cells to move from one intermediate target to another. Migrating cells themselves can function as sinks to create a gradient out of an initially uniform chemoattractant. These diverse ways of building sources and sinks allow different cell types to navigate distinct trajectories through the same embryo even as the whole embryo undergoes the dramatic changes in cell number, position, arrangement and fate that are the essence of development. </p>

DOI10.1016/j.ceb.2014.06.009
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID25022255
PubMed Central IDPMC4177943
Grant ListR01 GM046425 / GM / NIGMS NIH HHS / United States
R01GM46425 / GM / NIGMS NIH HHS / United States