Cell Motility

A major interest of the lab focuses on cell motility. Without cell migrations embryos could not develop, wounds would not heal and the nervous and immune systems could neither form nor function. But cell movements have a dark side, and the ability to move also contributes to tumor metastasis, which is a major cause of death for cancer patients. Denise Montell's lab has developed a new in vivo model for the study of collective, cooperative, cell-on-cell cell motility and employs a powerful combination of molecular genetics, live imaging and photo-manipulation techniques to decipher the molecular mechanisms that determine when, where and how cells move.

Affiliated Researchers

My laboratory uses a combination of molecular, genetic, and state-of-the-art imaging approaches to define and solve fundamental questions in cell and developmental biology.