The Rothman Lab























Callander DC1, Alcorn MR, Birsoy B, Rothman JH.(2014)  Natural reversal of left-right gut/gonad asymmetry in C. elegans males is independent of embryonic chirality.  Genesis. 2014 Mar 2. doi: 10.1002/dvg.22762. [Epub ahead of print] Abstract

Riddle MR, Weintraub A, Nguyen KC, Hall DH, Rothman JH (2013)Transdifferentiation and remodeling of post-embryonic C. elegans cells by a single transcription factor. Development Dec; 140(24):4844-9.  Abstract

Downes JC, Birsoy B, Chipman KC, Rothman JH (2012) Handedness of a motor program in C. elegans is independent of left-right body asymmetry.  PloS One 7 (12) :e52138.  Abstract

Djabrayan NJ, Dudley NR, Sommermann EM, Rothman JH (2012) Essential role for Notch signaling in restricting developmental plasticity. Genes Dev. Nov. 1; 26(21):2386-91. Abstract


Rothman JH, Singson A. (2011) Caenorhabditis elegans: molecular genetics and development. Methods Cell Biol. 106:xv-xviii.

Sommermann EM, Strohmaier KR, Maduro MF, Rothman JH (2010)Endoderm development in Caenorhabditis elegans: the synergistic action of ELT-2 and -7 mediates the specification→differentiation transition. Dev Biol. Nov 1;347(1):154-66.  Abstract


Pradeep M. Joshi, Misty R. Riddle, Nareg J.V. Djabrayan, Joel H. Rothman (2010). Caenorhabditis elegans as a model for stem cell biology. Developmental Dynamics. 239 (5) 1539-1554. Abstract

Putzke AP, Rothman JH (2010) Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci USA Sept 14; 107(37):16154-9.  Abstract

Joshi PM, Riddle MR, Djabrayan NJ, Rothman JH (2010) Caenorhabditis elegans as a model for stem cell biology.  Dev Dyn May; 239(5):1539-54.  Abstract

Witze, E., Field, E.D., Hunt, D.F., and Rothman, J.H. (2009) C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm. Dev. Biol 327: 12-23. Abstract

Maduro, M.F., and Rothman, J.H. (2009) Specification of the endoderm. Wormbook. M. Chalfie, and The C. elegans Research Community, eds..

Chen, L., McCloskey, T., Joshi, P.M., and Rothman, J.H. ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans. Curr. Biology 18:1025-33 (2008). [Featured in a Curr. Biol. minireview, Sept., 2008)] Abstract

Kumar, A., and Rothman, J.H. (2007) Cell death: Hook, line, and linker. Curr. Biology 17: R286-9. Abstract

Derry, W.B., Bierings, R., van Iersel, M., Satkunendran, T., Reinke, V., and Rothman, J.H. (2007) Regulation of developmental rate and germ cell proliferation in C. elegans by the p53 gene network. Cell Death Differ. 14: 662-670 . Abstract

Maduro, M.F, Broitman-Maduro, G., Mengarelli, I., and Rothman, J.H. (2007). Maternal deployment of the embryonic SKN-1 - MED-1,2 cell specification pathway in C. elegans. Dev. Biol 301: 590-60. Abstract

Fukuyama, M., Rougvie, A.E., and Rothman, J.H. (2006) C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline. Curr. Biol. 16, 773-779. Abstract


Maduro MF, Kasmir JJ, Zhu J, Rothman JH. (2005) The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development. Dev Biol. 285(2):510-23. Abstract

Joshi PM, Rothman JH. (2005) Nematode gastrulation: having a BLASTocoel!  Curr Biol. 15(13):R495-8. Abstract

Maduro MF, Hill RJ, Heid PJ, Newman-Smith ED, Zhu J, Priess JR, Rothman JH. (2005) Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev Bio. 284(2):509-22. Abstract

Kontani, K., and Rothman, J.H. (2005) Cell fusion: EFF is enough. Curr. Biol. 15, R252-254.

Putzke AP, Hikita ST, Clegg DO, Rothman JH. (2005) Essential kinase-independent role of a Fer-like non-receptor tyrosine kinase in Caenorhabditis elegans morphogenesis. Development 132(14): 3185-95. Abstract

Kontani, K, Moskowitz, IPG, and Rothman, JH. (2005) Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex. Developmental Cell 8 (5): 787-94. Abstract

Broitman-Maduro, G, Maduro, MF, and Rothman, JH. (2005) The non-canonical binding site of the MED-1 GATA factor defines differentially regulated target genes in the C. elegans mesendoderm. Developmental Cell 8 (3): 427-433. Abstract

Huyen, Y, Jeffrey, PD, Derry, WB, Rothman, JH, Pavletich, NP, Stavridi, ES, and Halazonetis, TD. (2004) Structural differences in the DNA binding domains of human p53 and its C. elegans orthologue Cep-1 Structure 12: 1237-43. Abstract

Reed, SI and Rothman, JH. (2004) Cell division, growth, and death. Curr. Op. Cell Biol. 16: 599-601. Abstract

Putzke, AP, and Rothman, JH. (2003) Gastrulation: PARtaking of the bottle. Curr. Biol. 13: R223-R225. Abstract

Bloss TA, Witze ES, and Rothman JH. (2003) Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans. Nature 424: 1066-1071. Abstract

Fukuyama M, Gendreau, SB, Derry WB, and Rothman, JH. (2003) Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans. Dev Biol 260: 273-286. Abstract

Koh, K, Peyrot, SM, Wood, CG, Wagmaister, JA, Maduro, MF, Eisenmann, DM, and Rothman, JH. (2002) Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors, apparent direct targets of the LIN-39 Hox protein. Development 129: 5171-5180. Abstract

Witze E, and Rothman JH (2002) Cell fusion: an EFFicient way to sculpt an animal. Curr. Biol. 12: R467-9. Abstract

Maduro MF, Lin R, and Rothman JH (2002) Dynamics of a developmental switch: recursive intracellular and intranuclear redistribution of C. elegans POP-1 parallels Wnt-inhibited transcriptional repression. Dev Biol 248: 128-142. Abstract

Maduro MF, and Rothman JH (2002) Making Worm Guts: The Gene Regulatory Network of the C. elegans Endoderm. Dev Biol 246(1):68-85. Abstract

Rothman JH (2002) Aging: from radiant youth to an abrupt end. Curr. Biol. 12: R239-41. Abstract

Calvo D, Victor M, Gay, F, Sui G, Luke MP-S, Dufourcq P, Wen G, Maduro M, Rothman JH, and Shi Y (2001) A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during C. elegans embryogenesis. EMBO J. 20(24): 7197-7208. Abstract

Kodama K, Rothman JH, Yamamoto M, and Sugimoto A (2001) cdl-1 encodes a stem-loop binding protein and is required for chromosome condensation, progression of programmed cell death, and morphogenesis in Caenorhabditis elegans. Development 129: 187-196. Abstract

Walker AK, Rothman JH, Shi Y, and Blackwell TK (2001) Distinct requirements for C. elegans TAFIIs in early embryonic transcription. EMBO J. 20: 5269-5279. Abstract

Derry WB, Putzke AP, Rothman JH (2001) C. elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance. Science 294: 591-595. (Published online 13 September 2001; 10.1126/science.1065486) Abstract

Heid PJ, Raich WB, Smith R, Mohler WA, Simokat K, Gendreau SB, Rothman JH, Hardin J. (2001) The zinc finger protein DIE-1 is required for late events during epithelial cell rearrangement in C. elegans. Dev Biol 236: 165-80. Abstract

Koh K, Rothman JH (2001) ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans. Development 128: 2857-2865. Abstract

Sugimoto A, Kusano A, Hozak, RR, Derry WB, Zhu J, Rothman JH (2001) Many Genomic Regions Are Required for Normal Embryonic Programmed Cell Death in Caenorhabditis elegans. Genetics 158: 237-252. Abstract

Maduro MF, Meneghini MD, Bowerman B, Broitman-Maduro G, Rothman JH (2001) Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3ß homolog is mediated by MED-1 and -2 in C. elegans. Molecular Cell 7(3): 475-485. (Cover Article) Abstract

Kaltenbach L, Horner MA, Rothman JH, Mango SE (2000) The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis. Mol Cell 6(3): 705-13. Abstract

Shoichet SA, Malik TH, Rothman JH, Shivdasani RA (2000) Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. PNAS 97(8): 4076-81. Abstract

Ferguson KC, Rothman JH (1999) Alterations in the conserved SL1 trans-spliced leader of Caenorhabditis elegans demonstrate flexibility in length and sequence requirements in vivo. Mol Cell Biol 19(3): 1892-900. Abstract

Zhu J, Fukushige T, McGhee JD, Rothman JH (1998) Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor. Genes Dev 12(24): 3809-14.Abstract

Newman-Smith ED, Rothman JH (1998) The maternal-to-zygotic transition in embryonic patterning of Caenorhabditis elegans. Curr Opin Genet Dev 8(4): 472-80. Abstract

Raich WB, Moran AN, Rothman JH, Hardin J (1998) Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Mol Biol Cell 9(8): 2037-49. Abstract

Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM (1998) Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.: PNAS 95(15): 8744-9. Abstract

Zhu J, Hill RJ, Heid PJ, Fukuyama M, Sugimoto A, Priess JR, Rothman JH (1997) end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos. Genes Dev 11(21): 2883-96. Abstract

Terns RM, Kroll-Conner P, Zhu J, Chung S, Rothman JH (1997) A deficiency screen for zygotic loci required for establishment and patterning of the epidermis in Caenorhabditis elegans. Genetics 146(1): 185-206. Abstract

Moskowitz IP, Rothman JH (1996) lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans. Development 122(12): 4105-17. Abstract

Ferguson KC, Heid PJ, Rothman JH (1996) The SL1 trans-spliced leader RNA performs an essential embryonic function in Caenorhabditis elegans that can also be supplied by SL2 RNA. Genes Dev 10(12): 1543-56. Abstract

Sugimoto A, Hozak RR, Nakashima T, Nishimoto T, Rothman JH (1995) dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. EMBO J 14(18): 4434-41. Abstract

Gendreau SB, Moskowitz IP, Terns RM, Rothman JH (1994) The potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans. Dev Biol 166(2): 770-81. Abstract

Moskowitz IP, Gendreau SB, Rothman JH (1994) Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans. Development 120(11): 3325-38. Abstract

Sugimoto A, Friesen PD, Rothman JH (1994) Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans. EMBO J 13(9): 2023-8. Abstract

Conference Abstracts and Publications (C. elegans WWW Server)


Rothman lab. Neuroscience Research Institute and

Department of Molecular, Cellular and Developmental Biology,

UC Santa Barbara, Santa Barbara, CA 93106