Dynamic regulation of the INAD signaling scaffold becomes crystal clear

TitleDynamic regulation of the INAD signaling scaffold becomes crystal clear
Publication TypeJournal Article
Year of Publication2007
AuthorsMontell C
JournalCell
Volume131
Pagination19-21
Date Published2007 Oct 5
ISSN0092-8674
KeywordsAnimals, Drosophila, Drosophila Proteins, Eye Proteins, Light, Oxidation-Reduction, PDZ Domains, Photoreceptor Cells, Invertebrate, Protein Conformation, Vision, Ocular
Abstract

PDZ domains are common building blocks of scaffold proteins that enhance specificity and speed in signal transduction cascades. Although PDZ modules are often viewed as passive participants, Mishra et al. (2007) now show that a PDZ domain in INAD, a scaffold protein in photoreceptor cells of the fruit fly, undergoes a light-dependent conformational change, which has important consequences for signaling and animal behavior.

DOI10.1016/j.cell.2007.09.022
Alternate JournalCell
PubMed ID17923082