Rapid release of Ca2+ from endoplasmic reticulum mediated by Na+/Ca2+ Exchange. J Neurosci. 40(16):3152-3164. . 2020.
Functions of opsins in Drosophila taste. Curr Biol. 30(8):1367-1379.e6. . 2020.
Temperature and sweet taste integration in Drosophila. Curr Biol. 30(11):2051-2067.e5. . 2020.
The Role of Y chromosome genes in male fertility in Drosophila melanogaster. Genetics. 215(3):623-633. . 2020.
A family of auxiliary subunits of the TRP cation channel encoded by the complex inaF locus. Genetics. 215(3):713-728. . 2020.
Coordinated movement: watching proprioception unfold. Curr Biol. 29:R202-R205. . 2019.
Mechanism of acetic acid gustatory repulsion in Drosophila. Cell Rep. 26:1432-1442.e4. . 2019.
Differential regulation of the sleep homeostat by circadian and arousal inputs. eLife. 8:e40487 . 2019.
Neuropeptide F regulates courtship in through a male-specific neuronal circuit. eLife. 8:e49574 . 2019.
pHirst sour taste channels pHound? Science. 359:991-992. . 2018.
The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism.. PLoS Biol. 16:e2005651. . 2018.
A Temperature Gradient Assay to Determine Thermal Preferences of Drosophila Larvae.. J Vis Exp. (136) . 2018.
Calcium taste avoidance in Drosophila. Neuron. 97:67-74. . 2018.
A rhodopsin in the brain functions in circadian photoentrainment in Drosophila. Nature. 545:340-344. . 2017.
Unconventional roles of opsins. Annu Rev Cell Dev Biol. 33:241-264. . 2017.
TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae. Nat Neurosci. 20:34-41. . 2017.
The basis of food texture sensation in Drosophila. Neuron. 91:863-77. . 2016.
Suppression of the motor deficit in a mucolipidosis type IV mouse model by bone marrow transplantation. Hum Mol Genet. 25:2752-62. . 2016.
A switch in thermal preference in Drosophila larvae depends on multiple rhodopsins. Cell Rep. 17:336-344. . 2016.
Structural insights into the Drosophila melanogaster retinol dehydrogenase, a member of the short-chain dehydrogenase/reductase family. Biochemistry. 55:6545-6557. . 2016.
Neuromodulation of courtship drive through tyramine-responsive neurons in the Drosophila brain. Curr Biol. 26:2246-56. . 2016.
Coordination and fine motor control depend on Drosophila TRPγ. Nat Commun. 6:7288. . 2015.
Forcing open TRP channels: Mechanical gating as a unifying activation mechanism. Biochem Biophys Res Commun. 460:22-25. . 2015.
RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. Mol Biol Cell. 26:3671-8. . 2015.
A Drosophila gustatory receptor required for strychnine sensation. Chem Senses. 40:525-33. . 2015.
TRP and rhodopsin transport depends on dual XPORT ER chaperones encoded by an operon. Cell Rep. 13:573-84. . 2015.
The full repertoire of Drosophila gustatory receptors for detecting an aversive compound. Nat Commun. 6:8867. . 2015.
Peripheral coding of taste. Neuron. 81:984-1000. . 2014.
Requirement for Drosophila SNMP1 for rapid activation and termination of pheromone-induced activity. PLoS Genet. 10(9):e1004600. . 2014.
Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol. 223:937-62. . 2014.
WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 82:151-66. . 2014.
Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci. 16:1468-76. . 2013.
An odorant-binding protein required for suppression of sweet taste by bitter chemicals. Neuron. 79:725-37. . 2013.
The molecular basis for attractive salt-taste coding in Drosophila. Science. 340:1334-8. . 2013.
Gustatory receptors: not just for good taste. Curr Biol. 23:R929-32. . 2013.
Drosophila TRPA1 functions in temperature control of circadian rhythm in pacemaker neurons. J Neurosci. 33:6716-25. . 2013.
Feast or famine: role of TRPML in preventing cellular amino acid starvation. Autophagy. 9:98-100. . 2013.
Drosophila TRP channels and animal behavior. Life Sci. 92:394-403. . 2013.
Gustatory receptors required for avoiding the insecticide L-canavanine. J Neurosci. 32:1429-35. . 2012.
Drosophila TRPML is required for TORC1 activation. Curr Biol. 22:1616-21. . 2012.
Drosophila visual transduction. Trends Neurosci. 35:356-63. . 2012.
The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. J Neurosci. 32:3485-91. . 2012.
Function of rhodopsin in temperature discrimination in Drosophila. Science. 331:1333-6. . 2011.
Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels. PLoS One. :e20031. . 2011.
The history of TRP channels, a commentary and reflection. Pflugers Arch. 461:499-506. . 2011.
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex. Science. 330:974-80. . 2010.
Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 20:1672-8. . 2010.
Avoiding DEET through insect gustatory receptors. Neuron. 67:555-61. . 2010.
Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction. J Neurosci. 30:11337-45. . 2010.
Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci. 30:10465-71. . 2010.
Drosophila TRPM channel is essential for the control of extracellular magnesium levels. PLoS One. 5:e10519. . 2010.
Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc Natl Acad Sci U S A. 107:8440-5. . 2010.
Preventing a Perm with TRPV3. Cell. 141:218-20. . 2010.
Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2. Proc Natl Acad Sci U S A. 107:4740-5. . 2010.
Requirement for an enzymatic visual cycle in Drosophila. Curr Biol. 20:93-102. . 2010.
A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship. Curr Biol. 19:1623-7. . 2009.
A taste of the Drosophila gustatory receptors. Curr Opin Neurobiol. 19:345-53. . 2009.
Multiple gustatory receptors required for the caffeine response in Drosophila. Proc Natl Acad Sci U S A. 106:4495-500. . 2009.
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell. 135:838-51. . 2008.
In search of the holy grail for Drosophila TRP. Neuron. 58:825-7. . 2008.
TRP channels: it's not the heat, it's the humidity. Curr Biol. 18:R123-6. . 2008.
A Drosophila model for LRRK2-linked parkinsonism. Proc Natl Acad Sci U S A. 105:2693-8. . 2008.
The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 57:56-68. . 2008.
Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 18:1797-801. . 2008.
Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. 11:871-3. . 2008.
Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Mol Cell. 25:491-503. . 2007.
Thermoregulation: channels that are cool to the core. Curr Biol. 17:R885-7. . 2007.
Dynamic regulation of the INAD signaling scaffold becomes crystal clear. Cell. 131:19-21. . 2007.
A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 104:14110-5. . 2007.
TRP channels. Annu Rev Biochem. 76:387-417. . 2007.
Phototransduction and retinal degeneration in Drosophila. Pflugers Arch. 454:821-47. . 2007.
Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol. 177:305-16. . 2007.
In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel. J Neurosci. 27:604-15. . 2007.
A mint of mutations in TRPM8 leads to cool results. Nat Neurosci. 9:466-8. . 2006.
Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response. Curr Biol. 16:723-9. . 2006.
A phosphoinositide synthase required for a sustained light response. J Neurosci. 26:12816-25. . 2006.
An exciting release on TRPM7. Neuron. 52:395-7. . 2006.
A taste receptor required for the caffeine response in vivo. Curr Biol. 16:1812-7. . 2006.
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem. 281:17517-27. . 2006.
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev. 57:427-50. . 2005.
Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol. 171:685-94. . 2005.
The latest waves in calcium signaling. Cell. 122:157-63. . 2005.
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron. 47:29-41. . 2005.
TRP channels in Drosophila photoreceptor cells. J Physiol. 567:45-51. . 2005.
Drosophila TRP channels. Pflugers Arch. 451:19-28. . 2005.
Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. J Neurosci. 25:5187-94. . 2005.
The TRP superfamily of cation channels. Sci STKE. 2005:re3. . 2005.
Take a TRP to beat the heat. Genes Dev. 19:415-8. . 2005.
Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development. Dev Dyn. 232:817-26. . 2005.
Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX. Neuron. 45:367-78. . 2005.
Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron. 43:95-103. . 2004.
From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms. Curr Opin Cell Biol. 16:115-8. . 2004.
Molecular genetics of Drosophila TRP channels. Novartis Found Symp. 258:3-12;discussion12-7,98-102,263-6. . 2004.
A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J. 23:811-22. . 2004.
Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr Biol. 14:2076-85. . 2004.
Exciting trips for TRPs. Nat Cell Biol. 6:690-2. . 2004.
Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A. 101:11874-9. . 2004.
A flagellar polycystin-2 homolog required for male fertility in Drosophila. Curr Biol. 13:2179-84. . 2003.
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 55:591-6. . 2003.
Mg2+ homeostasis: the Mg2+nificent TRPM chanzymes. Curr Biol. 13:R799-801. . 2003.
Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron. 39:121-32. . 2003.
TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol. 13:1153-8. . 2003.
Thermosensation: hot findings make TRPNs very cool. Curr Biol. 13:R476-8. . 2003.
The venerable inveterate invertebrate TRP channels. Cell Calcium. 33:409-17. . 2003.
Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt. J Neurosci. 22:3463-72. . 2002.
The TRP channels, a remarkably functional family. Cell. 108:595-8. . 2002.
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 9:229-31. . 2002.
Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci U S A. 98:10692-7. . 2001.
An end in sight to a long TRP. Neuron. 30:3-5. . 2001.
Regulation of the rhodopsin protein phosphatase, RDGC, through interaction with calmodulin. Neuron. 32:1097-106. . 2001.
Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci STKE. 2001:re1. . 2001.
TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells. J Cell Biol. 150:1411-22. . 2000.
A PDZ protein ushers in new links. Nat Genet. 26:6-7. . 2000.
TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron. 26:647-57. . 2000.
PLC fills a GAP in G-protein-coupled signalling. Nat Cell Biol. 2:E82-3. . 2000.
Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron. 24:261-73. . 1999.
Visual transduction in Drosophila. Annu Rev Cell Dev Biol. 15:231-68. . 1999.
Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci. 2:447-53. . 1999.
Requirement for the NINAC kinase/myosin for stable termination of the visual cascade. J Neurosci. 18:9601-6. . 1998.
Retinal targets for calmodulin include proteins implicated in synaptic transmission. J Biol Chem. 273:31297-307. . 1998.
TRP trapped in fly signaling web. Curr Opin Neurobiol. 8:389-97. . 1998.
Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J Cell Biol. 142:545-55. . 1998.
Calmodulin regulation of light adaptation and store-operated dark current in Drosophila photoreceptors. Proc Natl Acad Sci U S A. 94:5894-9. . 1997.
Calmodulin regulation of calcium stores in phototransduction of Drosophila. Science. 275:1119-21. . 1997.
New light on TRP and TRPL. Mol Pharmacol. 52:755-63. . 1997.
Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell. 89:1155-64. . 1997.
RIC, a calmodulin-binding Ras-like GTPase. EMBO J. 15:5839-48. . 1996.
TRPC1, a human homolog of a Drosophila store-operated channel. Proc Natl Acad Sci U S A. 92:9652-6. . 1995.
Calmodulin binding to Drosophila NinaC required for termination of phototransduction. EMBO J. 14:4450-9. . 1995.
Defective glia induce neuronal apoptosis in the repo visual system of Drosophila. Neuron. 14:581-90. . 1995.
Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development. Neuron. 13:67-81. . 1994.
repo encodes a glial-specific homeo domain protein required in the Drosophila nervous system. Genes Dev. 8:981-94. . 1994.
Dependence of calmodulin localization in the retina on the NINAC unconventional myosin. Science. 262:1038-42. . 1993.
Distinct roles of the Drosophila ninaC kinase and myosin domains revealed by systematic mutagenesis. J Cell Biol. 122:601-12. . 1993.
tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye. Genes Dev. 7:1085-96. . 1993.
Regulation of Drosophila neural development by a putative secreted protein. Differentiation. 52:1-11. . 1992.
Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin. J Biol Chem. 267:22542-9. . 1992.
Differential localizations of and requirements for the two Drosophila ninaC kinase/myosins in photoreceptor cells. J Cell Biol. 116:683-93. . 1992.
Molecular genetics of Drosophila vision. Bioessays. 11:43-8. . 1989.
Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Cell. 54:723-33. . 1988.
A second opsin gene expressed in the ultraviolet-sensitive R7 photoreceptor cells of Drosophila melanogaster. J Neurosci. 7:1558-66. . 1987.
Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science. 230:1040-3. . 1985.
Elimination of mRNA splicing by a point mutation outside the conserved GU at 5' splice sites. Nucleic Acids Res. 12:3821-7. . 1984.
Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol Cell Biol. 4:966-72. . 1984.
Complete transformation by adenovirus 2 requires both E1A proteins. Cell. 36:951-61. . 1984.
Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA. Nature. 305:600-5. . 1983.
Enhanced expression of adenovirus transforming proteins. J Virol. 44:276-85. . 1982.
Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature. 295:380-4. . 1982.