Activation of a TRPC3-dependent cation current through the neurotrophin BDNF

TitleActivation of a TRPC3-dependent cation current through the neurotrophin BDNF
Publication TypeJournal Article
Year of Publication1999
AuthorsLi HS, Xu XZ, Montell C
JournalNeuron
Volume24
Pagination261-73
Date Published1999 Sep
ISSN0896-6273
KeywordsAnimals, Brain-Derived Neurotrophic Factor, Cations, Cell Line, Cerebral Cortex, Electric Conductivity, Humans, Ion Channels, Neurons, Pons, Rats, Receptor, trkB, Tissue Distribution, Transfection, TRPC Cation Channels, Type C Phospholipases
Abstract

Nonvoltage-gated cation currents, which are activated following stimulation of phospholipase C (PLC), appear to be major modes for Ca2+ and Na+ entry in mammalian cells. The TRPC channels may mediate some of these conductances since their expression in vitro leads to PLC-dependent cation influx. We found that the TRPC3 protein was highly enriched in neurons of the central nervous system (CNS). The temporal and spatial distribution of TRPC3 paralleled that of the neurotrophin receptor TrkB. Activation of TrkB by brain-derived nerve growth factor (BDNF) led to production of a PLC-dependent, nonselective cation conductance in pontine neurons. Evidence is provided that TRPC3 contributes to this current in vivo. Thus, activation of TrkB and PLC leads to a TRPC3-dependent cation influx in CNS neurons.

Alternate JournalNeuron
PubMed ID10677043
Grant ListEY10852 / EY / NEI NIH HHS / United States