Intrinsic surface-drying properties of bioadhesive proteins.

TitleIntrinsic surface-drying properties of bioadhesive proteins.
Publication TypeJournal Article
Year of Publication2014
AuthorsAkdogan, Y, Wei, W, Huang, KY, Kageyama, Y, Danner, EW, Miller, DR, Rodriguez, NRMartinez, Waite, JH, Han, S
JournalAngew Chem Int Ed Engl
Date Published2014 Oct 13
KeywordsAdhesives, Adsorption, Animals, Bivalvia, Hydrophobic and Hydrophilic Interactions, Proteins, Surface Properties

Sessile marine mussels must "dry" underwater surfaces before adhering to them. Synthetic adhesives have yet to overcome this fundamental challenge. Previous studies of bioinspired adhesion have largely been performed under applied compressive forces, but such studies are poor predictors of the ability of an adhesive to spontaneously penetrate surface hydration layers. In a force-free approach to measuring molecular-level interaction through surface-water diffusivity, different mussel foot proteins were found to have different abilities to evict hydration layers from surfaces-a necessary step for adsorption and adhesion. It was anticipated that DOPA would mediate dehydration owing to its efficacy in bioinspired wet adhesion. Instead, hydrophobic side chains were found to be a critical component for protein-surface intimacy. This direct measurement of interfacial water dynamics during force-free adsorptive interactions at solid surfaces offers guidance for the engineering of wet adhesives and coatings.

Alternate JournalAngew. Chem. Int. Ed. Engl.
PubMed ID25168789
PubMed Central IDPMC4198389
Grant ListDP2 OD008702 / OD / NIH HHS / United States
R01 DE018468 / DE / NIDCR NIH HHS / United States
R01 DE018468 / DE / NIDCR NIH HHS / United States