New paper in eLife! The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

December 24, 2018

We got a new paper published in eLife! In this work we describe, for the first time, that co-translational protein targeting to the endoplasmic reticulum and the UPR, two processes long-thought to be autonomous, are coordinated in space and time through IRE1, the most evolutionarily conserved ER stress sensor. Using multiple orthogonal approaches we discovered that IRE1 physically interacts with ribosomes on the ER surface, possibly establishing a monitoring system to oversee the ER protein folding capacity. This exciting discovery portrays the UPR in a much more complex and dynamic picture in charge of coordinating ER homeostasis. Read it here.