We have two new papers, one in PNAS and one in Bio-protocol!
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-CAriel, Qing J, Totpal K, Kan D et al.. 2019. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. Here we describe the pharmacological targeting of the kinase domain of the key UPR effector IRE1 as a potential therapeutic for multiple myeloma.