Our latest preprint on a fast and simple method to extract RNA, DNA and protein to facilitate detection of SARS-CoV-2 detection is on bioRxiv. Check it out here: https://www.biorxiv.org/content/10.1101/2020.06.29.178384v1
We have two new papers, one in PNAS and one in Bio-protocol!
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-CAriel, Qing J, Totpal K, Kan D et al.. 2019. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. Here we describe the pharmacological targeting of the kinase domain of the key UPR effector IRE1 as a potential therapeutic for multiple myeloma.
Sabrina Solley, who was an undergraduate researcher in our lab, has joined as a Master's student in our Department's MA program. Congratulations Sabrina! We are delighted to have you in our group, and we wish you much success in your studies.
Carlos received the 2018 Lindros Award for Translating Research to Medical Practice of the UCSB Center for Bioengineering. This annual award is made possible by a generous donation from Carl and Jo Lindros.
Sabrina received the 2018 Doreen J. Putrah Cancer Research Foundation Fellowship for summer research.
Thank you to the donors for supporting our research, and congratulations Carlos and Sabrina!
As part of an international team effort, we reveal that blocking IRE1, a key component of the unfolded protein response (UPR), counterbalances atherosclerosis progression in a mouse model. The UPR is the stress response network of the endoplasmic reticulum. This study is proof-of-concept that the pharmacological targeting of the UPR can bring therapeutic benefit in this disease, and brings us one step closer to understanding the wiring of cellular stress response networks in health and disease.