News

November 01, 2019

Our most recent review on signal integration mechanisms in the UPR is out! You can read it here.

August 07, 2019

We have two new papers, one in PNAS and one in Bio-protocol!

Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-CAriel, Qing J, Totpal K, Kan D et al..  2019. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci U S A. Here we describe the pharmacological targeting of the kinase domain of the key UPR effector IRE1 as a potential therapeutic for multiple myeloma.

July 07, 2019

Dr. Francesca Zappa joins our lab! Welcome Zappa! We wish you much success in your post-doctoral studies.

May 28, 2019

Michael decided to join our lab for his Ph.D. Welcome! We are excited to have you in our lab community and we wish you much success in your research.

June 29, 2018

Sabrina Solley, who was an undergraduate researcher in our lab, has joined as a Master's student in our Department's MA program. Congratulations Sabrina! We are delighted to have you in our group, and we wish you much success in your studies.

June 29, 2018

Carlos received the 2018 Lindros Award for Translating Research to Medical Practice of the UCSB Center for Bioengineering. This annual award is made possible by a generous donation from Carl and Jo Lindros. 

Sabrina received the 2018 Doreen J. Putrah Cancer Research Foundation Fellowship for summer research.

Thank you to the donors for supporting our research, and congratulations Carlos and Sabrina!

February 12, 2018

José Carlos Ponce Rojas has chosen our lab to conduct his postdoctoral work. We are delighted to have you in our group Carlos, and we wish you much success in your studies!

January 26, 2018

Nerea L. Muniozguren has chosen our lab to conduct her PhD studies. We are delighted to have you in our group Nerea, and we wish you much success in your studies!

January 24, 2018

Welcome Anastasiya, Megan, Neda, Shakuntala, Lauren, and Soham! We are very happy to have you as part of our team.

July 13, 2017

Looking for a home lab? find info here

June 22, 2017

Welcome Fritzi! We are delighted to have you in the lab.

June 16, 2017

We are very excited and honored ot receive this prestigious Award!  Our deepest gratitude to the UCSB Academic Senate Faculty Grants Program and to Chancellor Henry T. Yang.

January 30, 2017

As part of an international team effort, we reveal that blocking IRE1, a key component of the unfolded protein response (UPR), counterbalances atherosclerosis progression in a mouse model. The UPR is the stress response network of the endoplasmic reticulum. This study is proof-of-concept that the pharmacological targeting of the UPR can bring therapeutic benefit in this disease, and brings us one step closer to understanding the wiring of cellular stress response networks in health and disease.