Recent advances in signal integration mechanisms in the unfolded protein response.

TitleRecent advances in signal integration mechanisms in the unfolded protein response.
Publication TypeJournal Article
Year of Publication2019
AuthorsG Karagöz E, Aragón T, Acosta-Alvear D
JournalF1000Res
Volume8
Date Published2019
ISSN2046-1402
Abstract

Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the cell. However, if ER homeostasis is unattainable, the UPR switches to drive cell death to remove defective cells in an effort to protect the health of the organism. This functional dichotomy places the UPR at the crossroads of the adaptation versus apoptosis decision. Here, we focus on new developments in UPR signaling mechanisms, in the interconnectivity among the signaling pathways that make up the UPR in higher eukaryotes, and in the coordination between the UPR and other fundamental cellular processes.

DOI10.12688/f1000research.19848.1
Alternate JournalF1000Res
PubMed ID31723416
PubMed Central IDPMC6833987