Publications

Found 14 results
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Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M et al..  2015.  Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.. Mol Cancer Ther. 14(3):642-8.
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Karagöz GElif, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P.  2017.  An unfolded protein-induced conformational switch activates mammalian IRE1.. Elife. 6
G Karagöz E, Acosta-Alvear D, Walter P.  2019.  The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.. Cold Spring Harb Perspect Biol.
Acosta-Alvear D, Karagöz GElif, Fröhlich F, Li H, Walther TC, Walter P.  2018.  The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1.. Elife. 7
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Tufanli O, Akillilar PTelkoparan, Acosta-Alvear D, Kocaturk B, Onat UInci, Hamid SMuhammad, Çimen I, Walter P, Weber C, Erbay E.  2017.  Targeting IRE1 with small molecules counteracts progression of atherosclerosis.. Proc Natl Acad Sci U S A.
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Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK-H, Wilson C et al..  2013.  Pharmacological brake-release of mRNA translation enhances cognitive memory.. Elife. 2:e00498.
Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I et al..  2015.  Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.. Elife. 4:e08153.
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Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A.  2014.  Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.. Science. 345(6192):98-101.
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Dufey E, San Pedro JManuel Bra, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y et al..  2020.  Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.. Nat Commun. 11(1):2401.
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Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV et al..  2015.  Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.. Elife. 4
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Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-CAriel, Qing J, Totpal K, Kan D et al..  2019.  Disruption of IRE1α through its kinase domain attenuates multiple myeloma.. Proc Natl Acad Sci U S A.
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Peschek J, Acosta-Alvear D, Mendez AS, Walter P.  2015.  A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing.. EMBO Rep. 16(12):1688-98.
Behrman S, Acosta-Alvear D, Walter P.  2011.  A CHOP-regulated microRNA controls rhodopsin expression.. J Cell Biol. 192(6):919-27.
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Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA et al..  2016.  Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.. J Clin Invest.