Pluripotent human stem cells for the treatment of retinal disease

TitlePluripotent human stem cells for the treatment of retinal disease
Publication TypeJournal Article
Year of Publication2012
AuthorsRowland TJ, Buchholz DE, Clegg DO
JournalJournal of Cellular Physiology
Date Published2012 Feb
KeywordsCell Differentiation, Embryonic Stem Cells, Humans, Pluripotent Stem Cells, Retinal Diseases, Stem Cell Transplantation

Despite advancements made in our understanding of ocular biology, therapeutic options for many debilitating retinal diseases remain limited. Stem cell-based therapies are a potential avenue for treatment of retinal disease, and this mini-review will focus on current research in this area. Cellular therapies to replace retinal pigmented epithelium (RPE) and/or photoreceptors to treat age-related macular degeneration (AMD), Stargardt's macular dystrophy, and retinitis pigmentosa are currently being developed. Over the past decade, significant advancements have been made using different types of human stem cells with varying capacities to differentiate into these target retinal cell types. We review and evaluate pluripotent stem cells, both human embryonic stem cells and human induced pluripotent stem cells, as well as protocols for differentiation of ocular cells, and culture and transplant techniques that might be used to deliver cells to patients.

Alternate JournalJ. Cell. Physiol.
PubMed ID21520078