Publications

Found 67 results
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2022
Kashani AH, Lebkowski JS, Hinton DR, Zhu D, Faynus MA, Chen S, Rahhal FM, Avery RL, Salehi-Had H, Chan C et al..  2022.  Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration.. Stem Cell Reports. 17(3):448-458.
2021
Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Chen S, Chan C, Palejwala N, Ingram A, Dang W et al..  2021.  One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration.. Transl Vis Sci Technol. 10(10):13.
Pennington BO, Bailey JK, Faynus MA, Hinman C, Hee MN, Ritts R, Nadar V, Zhu D, Mitra D, Martinez-Camarillo JCarlos et al..  2021.  Xeno-free cryopreservation of adherent retinal pigmented epithelium yields viable and functional cells in vitro and in vivo.. Sci Rep. 11(1):6286.
2020
Kashani AH, Uang J, Mert M, Rahhal F, Chan C, Avery RL, Dugel P, Chen S, Lebkowski J, Clegg DO et al..  2020.  Surgical Method for Implantation of a Biosynthetic Retinal Pigment Epithelium Monolayer for Geographic Atrophy: Experience from a Phase 1/2a Study.. Ophthalmol Retina. 4(3):264-273.
2019
Toh H, Smolentsev A, Bozadjian RV, Keeley PW, Lockwood MD, Sadjadi R, Clegg DO, Blodi BA, Coffey PJ, Reese BE et al..  2019.  Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.. Lab Invest. 99(10):1547-1560.
2018
Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin C-M, Mitra D, Zhu D, Thomas BB et al..  2018.  A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.. Science Translational Medicine. 10(435)
Foltz LP, Howden SE, Thomson JA, Clegg DO.  2018.  Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9.. Int J Mol Sci. 19(12)
Foltz LP, Clegg DO.  2018.  Patient-derived induced pluripotent stem cells for modelling genetic retinal dystrophies.. Progress in Retinal and Eye Research.
2017
Siegel KR, Clevenger TN, Clegg DO, Proctor DA, Proctor CS.  2017.  Adipose Stem Cells Incorporated in Fibrin Clot Modulate Expression of Growth Factors. Arthroscopy.
Lin T-C, Seiler MJ, Zhu D, Falabella P, Hinton DR, Clegg DO, Humayun MS, Thomas BB.  2017.  Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells Int. 2017:9428176.
Gornalusse GG, Hirata RK, Funk SE, Riolobos L, Lopes VS, Manske G, Prunkard D, Colunga AG, Hanafi L-A, Clegg DO et al..  2017.  HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells. Nat Biotechnol.
Foltz LP, Clegg DO.  2017.  Rapid, Directed Differentiation of Retinal Pigment Epithelial Cells from Human Embryonic or Induced Pluripotent Stem Cells. J Vis Exp. (128)
2016
Clevenger TN, Luna G, Boctor D, Fisher SK, Clegg DO.  2016.  Cell-mediated remodeling of biomimetic encapsulating hydrogels triggered by adipogenic differentiation of adipose stem cells. J Tissue Eng. 7:2041731416670482.
Leach LL, Croze RH, Hu Q, Nadar VP, Clevenger TN, Pennington BO, Gamm DM, Clegg DO.  2016.  Induced Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium: A Comparative Study Between Cell Lines and Differentiation Methods. J Ocul Pharmacol Ther. 32(5):317-30.
Fernandes RABrant, Koss MJanusz, Falabella P, Stefanini FRosa, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg DO et al..  2016.  An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surgery, Lasers Imaging Retina. 47(4):342-51.
Huang X, Hu Q, Lai Y, Morales DP, Clegg DO, Reich NO.  2016.  Light-Patterned RNA Interference of 3D-Cultured Human Embryonic Stem Cells. Adv Mater. 28(48):10732-10737.
Pennington BO, Clegg DO.  2016.  Pluripotent Stem Cell-Based Therapies in Combination with Substrate for the Treatment of Age-Related Macular Degeneration. Journal of Ocular Pharmacology & Therapeutics.
Clegg DO.  2016.  Regenerating Perfection. J Ocul Pharmacol Ther. 32(5):237.
Croze RH, Thi WJ, Clegg DO.  2016.  ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium. Transl Vis Sci Technol. 5(6):7.
Clevenger TN, Luna G, Fisher SK, Clegg DO.  2016.  Strategies for bioengineered scaffolds that support adipose stem cells in regenerative therapies. Regenerative Medicine.
Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR et al..  2016.  Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 254(8):1553-65.
Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton DR et al..  2016.  Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Invest Ophthalmol Vis Sci. 57(6):2877-87.
Clevenger TN, Hinman CR, Rubin RKAshley, Smither K, Burke DJ, Hawker CJ, Messina D, Van Epps D, Clegg DO.  2016.  Vitronectin-Based, Biomimetic Encapsulating Hydrogel Scaffolds Support Adipogenesis of Adipose Stem Cells. Tissue Engineering Part A. 22(7-8):597-609.
2015
Leach LL, Buchholz DE, Nadar VP, Lowenstein SE, Clegg DO.  2015.  Canonical/β-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells. Investigative Ophthalmology & Visual Science. 56(2):1002-13.
Forest DL, Johnson LV, Clegg DO.  2015.  Cellular models and therapies for age-related macular degeneration. Disease Models & Mechanisms. 8(5):421-7.

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