Publications

Found 25 results
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2022
Kashani AH, Lebkowski JS, Hinton DR, Zhu D, Faynus MA, Chen S, Rahhal FM, Avery RL, Salehi-Had H, Chan C et al..  2022.  Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration.. Stem Cell Reports. 17(3):448-458.
2021
Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Chen S, Chan C, Palejwala N, Ingram A, Dang W et al..  2021.  One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration.. Transl Vis Sci Technol. 10(10):13.
Pennington BO, Bailey JK, Faynus MA, Hinman C, Hee MN, Ritts R, Nadar V, Zhu D, Mitra D, Martinez-Camarillo JCarlos et al..  2021.  Xeno-free cryopreservation of adherent retinal pigmented epithelium yields viable and functional cells in vitro and in vivo.. Sci Rep. 11(1):6286.
2018
Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin C-M, Mitra D, Zhu D, Thomas BB et al..  2018.  A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.. Science Translational Medicine. 10(435)
2015
Forest DL, Johnson LV, Clegg DO.  2015.  Cellular models and therapies for age-related macular degeneration. Disease Models & Mechanisms. 8(5):421-7.
2013
Clegg DO, Hikita ST, Hu Q, Buchholz DE, Rowland TJ, Conti L, Pennington B, Croze R, Leach L, Tsie M et al..  2013.  Derivation of retinal pigmented epithelial cells from pluripotent stem cells. The Stem Cell Handbook.
Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV, Clegg DO.  2013.  Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. Journal of Tissue Engineering and Regenerative Medicine. 7(8):642-53.
Hikita S, Clegg D, Johnson L, Miller L, Tsie M, Presbrey C, Conti L, Maloney M, Hinton D, Hu Q et al..  2013.  Methods of Culturing Retinal Pigmented Epithelium Cells, Including Xeno-Free Production, RPE Enrichment, and Cryopreservation.
2012
Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton DR, Tai Y-C et al..  2012.  A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Research. 48(4):186-91.
2011
Humayun M, Ahuja A, Tai Y-C, Hinton D, Grubbs R, Clegg D, JOHNSON LVallance, Hikita ST, .  2011.  Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same.
2010
Hu Q, Friedrich AM, Johnson LV, Clegg DO.  2010.  Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells. 28(11):1981-91.
Rowland TJ, Miller LM, Blaschke AJ, E Doss L, Bonham AJ, Hikita ST, Johnson LV, Clegg DO.  2010.  Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin. Stem Cells & Development. 19(8):1231-40.
2009
Buchholz DE, Hikita ST, Rowland TJ, Friedrich AM, Hinman CR, Johnson LV, Clegg DO.  2009.  Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells. 27(10):2427-34.
Carr A-J, Vugler AA, Hikita ST, Lawrence JM, Gias C, Chen LLi, Buchholz DE, Ahmado A, Semo M'ayan, Smart MJK et al..  2009.  Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PLoS One. 4(12):e8152.
2008
Clegg DO, Buchholz D, Hikita S, Rowland T, Hu Q, Johnson LV.  2008.  Retinal pigment epithelial cells: development in vivo and derivation from human embryonic stem cells in vitro for treatment of age-related macular degeneration. Stem Cell Research and Therapeutics. :1–24.
Buchholz DE, Hikita ST, Radeke MJ, Blashke KE, Johnson LV, Clegg DO.  2008.  Stem cell derived retinal pigment Epithelium for the treatment of age-related Macular degeneration. Journal of Vision. 8:47–47.
2006
Hikita ST, Vistica BP, Jones HR, Keswani JR, Watson MM, Ericson VR, Ayoub GS, Gery I, Clegg DO.  2006.  Osteopontin is proinflammatory in experimental autoimmune uveitis. Investigative Ophthalmology & Visual Science. 47(10):4435-43.
2005
Wingerd KL, Wayne WC, Jackson DY, Clegg DO.  2005.  Involvement of alpha4 integrins in maintenance of cardiac sympathetic axons. Autonomic Neuroscience. 122(1-2):58-68.
2004
Leu ST, Jacques SAL, Wingerd KL, Hikita ST, Tolhurst EC, Pring JL, Wiswell D, Kinney L, Goodman NL, Jackson DY et al..  2004.  Integrin alpha4beta1 function is required for cell survival in developing retina. Developmental Biology. 276(2):416-30.
Leu ST, Jacques SAL, Wingerd KL, Hikita ST, Tolhurst EC, Pring JL, Wiswell D, Kinney L, Goodman NL, Jackson DY et al..  2004.  Integrin alpha4beta1 function is required for cell survival in developing retina. Developmental Biology. 276(2):416-30.
2002
Wingerd KL, Goodman NL, Tresser JW, Smail MM, Leu ST, Rohan SJ, Pring JL, Jackson DY, Clegg DO.  2002.  Alpha4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart. The Journal of Neuroscience. 22(24):10772-80.
Clegg DO, Leu ST, Batni S, Radeke MJ, Johnson LV, Anderson DH.  2002.  Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration. Investigative Ophtalmology & Visual Science. 43:697.
Leu ST, Batni S, Radeke MJ, Johnson LV, Anderson DH, Clegg DO.  2002.  Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration. Experimental Eye Research. 74(1):141-54.
Clegg DO, Leu ST, Jacques S, Wingerd KL, Goodman N.  2002.  Inhibition of integrin alpha4/beta1 in developing chick retina results in increased apoptosis. Molecular Biology of the Cell. 13:482A–483A.
1997
Lin H, Anderson DH, Johnson LV, Clegg DO.  1997.  Exposure of ROS to serum facilitates ROS phagocytosis by cultured human RPE. Investigative Ophthalmology & Visual Science. 38:1541–1541.