Protein targeting to the yeast vacuole.

TitleProtein targeting to the yeast vacuole.
Publication TypeJournal Article
Year of Publication1989
AuthorsRothman JH, Yamashiro CT, Kane PM, Stevens TH
JournalTrends Biochem Sci
Date Published1989 Aug
KeywordsGenes, Fungal, Hydrogen-Ion Concentration, Mutation, Protein Sorting Signals, Proton-Translocating ATPases, Saccharomyces cerevisiae, Vacuoles, Yeasts

Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H+-ATPase, presumably via its role in vacuolar acidification.

Alternate JournalTrends Biochem. Sci.
PubMed ID2529676