Biological Fidelity and Robustness
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Researchers
Molly Kirk
I am interested in the molecular mechanisms by which complex organisms, specifically the nervous system of complex organisms, survive extreme environmental challenges. To answer these questions, I use the extremely tolerant Tardigrade, a unique invertebrate clade renowned for its ability to survive, complete desiccation, hypoxia, the vacuum of space, and radiation 1000 times the dosage of other animals! I am currently pursuing three avenues of research in the lab.
Juwel Chandra Baray
My research is centered on understanding transdifferentiation, transorganogenesis, and the intriguing fields of aging and longevity in the nematode C. elegans. Furthermore, my objective is to bridge the gap between human biology and model organisms by applying these insights to the context of human cells.
Anna Jellema-Butler
I am interested in understanding the mechanisms controlling healthspan and lifespan, including the role of genetic and epigenetic factors, natural and artificial rejuvenation events, and dietary and behavioral interventions. I work with the premier aging model of C. elegans and focus on leveraging large-scale biological data through the use of statistics and bioinformatics.
Jonathan Paules
My work focuses on elucidating the variety of mechanisms tardigrades incorporate to survive extreme conditions. My current projects include developing a novel feeding assay, studying stress response pathways, and increasing the tools we have to study these incredible animals.
Paige Shukwit
My focus is on understanding how tardigrades respond to extreme environments, specifically ranging pH levels.
Emma Abbate
I am working with Paige to study how tardigrades respond to extreme pHs. Specifically, I am studying the effect that extreme pHs have on the reproduction patterns of tardigrades as well as tardigrade pH preference.
Nikolas Belle
I work with Sierra Klier on using machine learning models for genome annotation of tardigrades. We are particularly interested in using these models to uncover the genetic mechanisms behind tardigrade extremotolerance.
Sydney Fetters
I am currently assisting in continuing the research of Dr. Ackley by studying the different mechanosensory pathway systems responsible to how C. Elegans exhibit negative gravitaxis behavior. As well as assisting Dr. Kirk as part of the Proofreading Team for studying tardigrade neuronal pathways and system development.
Katrina Ortman
I currently assist Jonathan on his project aiming to genetically modify algae to induce RNAi in tardigrades. I'm also investigating algal cryofreezing procedures / supernatants and algal flocculation for tardigrade feeding.
