Evolutionary and Quantitative Genetics
Regulation of development and differentiation; regulation of programmed cell death and cell division; mechanisms of tumorigenesis
I study questions of cell fate, with cell death being one of those possible fates. I am researching the role of PINK-1, a mitochondrial kinase, in apoptosis, as pink-1 mutants show a decrease in programmed cell death. I am also studying endoderm cell fate by examining the factors necessary to reprogram an already differentiated cell into a morphological gut cell and by examining possible connections between stress response and endoderm development.
I’m interested in understanding how environmental stress is translated into epigenetic information which can potentially be transmitted transgenerationally. I’m also investigating variation in behavioural responses exists among C. elegans wild isolates.
I study different mutant strains of C elegans and determine what mutations on different chromosomes could stop transorganogenesis in those worms.