Evolutionary and Quantitative Genetics
Regulation of development and differentiation; regulation of programmed cell death and cell division; mechanisms of tumorigenesis
My research focus is on trans-differentiation, trans-organogenesis, and aging and longevity in nematode C. elegans.
The small roundworm Caenorhabditis elegans has a relatively short wild type lifespan (about 18-20 days) and an easily manipulated genome which has made it an attractive subject for longevity screening over the past four decades. These longevity screens, however, are limited in scale. I am working with Dr. Rothman and Dr. Joshi to develop a new method for longevity screening that is conducive to scalability and compatibility with other model organisms. This new methodology has the potential to identify mutants with maximum lifespans magnitudes greater than their wild type counterparts.