| Title | TGF beta inhibitors. New and unexpected requirements in vertebrate development. |
| Publication Type | Journal Article |
| Year of Publication | 1999 |
| Authors | Smith WC |
| Journal | Trends Genet |
| Volume | 15 |
| Issue | 1 |
| Pagination | 3-5 |
| Date Published | 1999 Jan |
| ISSN | 0168-9525 |
| Keywords | Animals, Bone Morphogenetic Proteins, Carrier Proteins, Congenital Abnormalities, Embryonic and Fetal Development, Extremities, Fetal Proteins, Follistatin, Glycoproteins, Hedgehog Proteins, Intercellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Models, Biological, Morphogenesis, Multigene Family, Proteins, Signal Transduction, Somites, Trans-Activators, Transforming Growth Factor beta, Xenopus laevis |
| Abstract | Analysis of embryonic induction has pointed to the importance of the antagonistic roles played by secreted inducing factors and their soluble inhibitory binding proteins. These interactions have been particularly well characterized in patterning the primary axes of insects and vertebrates. New results implicate similar antagonistic relationships in numerous later events of embryogenesis. |
| Alternate Journal | Trends Genet. |
| PubMed ID | 10087923 |