| Title | Synthetic surfaces for human embryonic stem cell culture |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kolhar P, Kotamraju VRamana, Hikita ST, Clegg DO, Ruoslahti E |
| Journal | Journal of Biotechnology |
| Volume | 146 |
| Issue | 3 |
| Pagination | 143-6 |
| Date Published | 2010 Apr 1 |
| ISSN | 1873-4863 |
| Keywords | Cell Culture Techniques, Cell Proliferation, Cell Survival, Cells, Cultured, Embryonic Stem Cells, Extracellular Matrix, Humans, Oligopeptides, Tissue Engineering |
| Abstract | Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions. |
| DOI | 10.1016/j.jbiotec.2010.01.016 |
| Alternate Journal | J. Biotechnol. |
| PubMed ID | 20132848 |