NEGotiating Cell Identity through Regulated Cytoplasmic Polyadenylation.

TitleNEGotiating Cell Identity through Regulated Cytoplasmic Polyadenylation.
Publication TypeJournal Article
Year of Publication2015
AuthorsJoshi PM, Rothman JH
JournalDev Cell
Volume34
Issue1
Pagination1-2
Date Published2015 Jul 6
ISSN1878-1551
KeywordsAnimals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Carrier Proteins, Cytoplasm, Nuclear Proteins, Polyadenylation, RNA, Helminth, RNA, Messenger
Abstract

In this issue of Developmental Cell, Elewa et al. (2015) show that combinatorial action of RNA binding proteins modulates poly(A) tail length of maternal mRNAs, leading to asymmetric expression of a cell fate determinant in early C. elegans embryos. Genome-wide profiling suggests this mechanism may be widely used to establish cell identities.

DOI10.1016/j.devcel.2015.06.022
Alternate JournalDev. Cell
PubMed ID26151901