Title | Essential role for Notch signaling in restricting developmental plasticity. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Djabrayan NJ-V, Dudley NR, Sommermann EM, Rothman JH |
Journal | Genes Dev |
Volume | 26 |
Issue | 21 |
Pagination | 2386-91 |
Date Published | 2012 Nov 1 |
ISSN | 1549-5477 |
Keywords | Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Differentiation, Cellular Reprogramming, Embryonic Development, Gene Expression Regulation, Developmental, Receptors, Notch, Signal Transduction |
Abstract | We report that Notch signaling is essential for the switch from developmental plasticity to commitment during Caenorhabditis elegans embryogenesis. The GLP-1 and LIN-12 Notch receptors act to set a memory state that affects commitment of cells arising from the major ectodermal progenitor (AB blastomere) several cell divisions later, thereby preventing their forced reprogramming by an endoderm-determining transcription factor. In contrast to Notch-dependent cell fate induction, this activity is autonomous to the AB lineage, is independent of the known cell fate-inducing Notch ligands, and requires a putative secreted Notch ligand, Delta Serrate Lag-3 (DSL-3). Thus, Notch signaling promotes developmental commitment by a mechanism that is distinct from that involved in specifying cell fates. |
DOI | 10.1101/gad.199588.112 |
Alternate Journal | Genes Dev. |
PubMed ID | 23124064 |
PubMed Central ID | PMC3489997 |
Grant List | HD062922 / HD / NICHD NIH HHS / United States |