Alumni

Project Scientists

Seng Hui Low, PhD

Present Position: 
Lecturer, Department of Molecular, Cellular, and Developmental Biology, UCSB
Years in Lab: 
1999-2012 (Support: American Heart Association, Scientist Development Grant, 2002-2006)
Publications from Lab: 

Soo-Hoo L, Banna CD, Radeke CM, Sharma N, Albertolle ME, Low SH, Weimbs T, Vandenberg CA. The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. PLoS One. 2016 ;11(9):e0163671.

Reales E, Sharma N, Low SH, Fölsch H, Weimbs T. Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity. PLOS One. 2011 ;6:e21181.

Reales E, Sharma N, Low SH, Fölsch H, Weimbs T. Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity. PLOS One. 2011 ;6:e21181.

Sharma N, Low SH, Misra S, Pallavi B, Weimbs T. Apical targeting of syntaxin 3 is essential for epithelial cell polarity. The Journal of Cell Biology. 2006 ;173:937–948.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Developmental Cell. 2006 ;10:57–69.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2006 ;103:5466–5471.

Kidd GJ, Yadav VK, Huang P, Brand SL, Low SH, Weimbs T, Trapp BD. A dual tyrosine-leucine motif mediates myelin protein P0 targeting in MDCK cells. Glia. 2006 ;54:135–145.

Sherief MH, Low SH, Miura M, Kudo N, Novick AC, Weimbs T. Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay. The Journal of Urology. 2003 ;169:1530–1534.

Weimbs T, Low SH, Li X, Kreitzer G. SNAREs and epithelial cells. Methods. 2003 ;30:191–197.

Low SH, Li X, Miura M, Kudo N, Quiñones B, Weimbs T. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Developmental Cell. 2003 ;4:753–759.

Kreitzer G, Schmoranzer J, Low SH, Li X, Gan Y, Weimbs T, Simon SM, Rodriguez-Boulan E. Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nature Cell Biology. 2003 ;5:126–136.

Li X, Low SH, Miura M, Weimbs T. SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes. American Journal of Physiology-Renal Physiology. 2002 ;283:F1111–F1122.

Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T. Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Journal of Cell Science. 2002 ;115:4545–4553.

Lim S-N, Bonzelius F, Low SH, Wille H, Weimbs T, Herman GA. Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins. Molecular Biology of the Cell. 2001 ;12:981–995.

Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T. Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity. Molecular Biology of the Cell. 2000 ;11:3045–3060.

Jayasri Nanduri, PhD

Present Position: 
Associate Professor, University of Chicago, Department of Medicine
Years in Lab: 
2002-2004
Publications from Lab: 

Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Molecular Biology of the Cell. 2006 ;17:977–989.

Jonathan Shillingford, PhD

Present Position: 
Research Assistant Professor, Division of Nephrology, University of Michigan
Years in Lab: 
2003-2012 (Support: American Heart Association, Scientist Development Grant, 2006-2010)
Publications from Lab: 

Kipp KR, Kruger SL, Schimmel MF, Parker N, Shillingford JM, Leamon CP, Weimbs T. Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2018 ;315:F395–F405.

Stayner C, Shields J, Slobbe L, Shillingford JM, Weimbs T, Eccles MR. Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1-/- mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the foetus. Nephrology. 2012 ;17:739–747.

Shillingford JM, Leamon CP, Vlahov IR, Weimbs T. Folate-conjugated rapamycin slows progression of polycystic kidney disease. Journal of the American Society of Nephrology. 2012 ;23:1674.

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2011 ;108:18067–18072.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T. Polycystin-1 regulates STAT activity by a dual mechanism. Proceedings of the National Academy of Sciences. 2011 ;108:7985–7990.

Shillingford JM, Piontek KB, Germino GG, Weimbs T. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. Journal of the American Society of Nephrology. 2010 ;21:489–497.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2006 ;103:5466–5471.

Fei B, Flask C, Wang H, Pi A, Wilson DL, Shillingford J, Murcia N, Weimbs T, Duerk JL. Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. Engineering in Medicine and Biology Society, 2005. Conf Proc IEEE Eng Med Biol Soc. 2005 :467–469.

Rashid Syed, PhD

Present Position: 
Faculty, Department of Chemistry and Biochemistry, California State University Northridge
Years in Lab: 
2007-2009

Postdoctoral Researchers

Pallavi Bhattaram, PhD

Present Position: 
Assistant Professor, Emory University School of Medicine
Years in Lab: 
2004-2006
Publications from Lab: 

Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018 ;293:5478-5491.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells. Bio-Protocol. 2018 ;8(3):e2453.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Mono-ubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes. Mol Biol Cell. 2017 ;28:2843-2853.

Nicholas Doerr, PhD

Present Position: 
Director of Research, Bioniz Therapeutics, Irvine, CA
Years in Lab: 
2006-2015
Awards & Funding: 
Philip & Aida Siff Educational Foundation Graduate Fellowship (2009/10)
Publications from Lab: 

Olsan EE, West JD, Torres JA, Doerr N, Weimbs T. Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease. Am J Physiol Renal Physiol. 2018 ;315:F86–F96.

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 ;11(8):e0161525.

Rothé B, Leal-Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, Iwaszkiewicz J, Constam DB. Bicc1 polymerization regulates the localization and silencing of bound mRNA. Mol Cell Biol. 2015 ;35:3339-3353.

Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T. The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 2014 ;25(8):1737-48.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T. Polycystin-1 regulates STAT activity by a dual mechanism. Proceedings of the National Academy of Sciences. 2011 ;108:7985–7990.

Adrian Giovannone, PhD

Present Position: 
Scientist Bioniz, Irvine, California
Years in Lab: 
2008-2017
Publications from Lab: 

Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018 ;293:5478-5491.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells. Bio-Protocol. 2018 ;8(3):e2453.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Mono-ubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes. Mol Biol Cell. 2017 ;28:2843-2853.

Olsan, E.E., Mukherjee, S., Wulkersdorfer, B., Shillingford, J.M., Giovannone, A.J., Todorov, G., Song, X., Pei, Y., and Weimbs, T. (2011). Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences of the United States of America 108, 18067-18072.

Xin Li, MD, PhD

Present Position: 
Clinical Pathologist, University Hospitals, Richmond Heights, OH
Years in Lab: 
2000-2003 (Support: Department of Defense Prostate Cancer Research Program, Research Grant)
Publications from Lab: 

Weimbs T, Low SH, Li X, Kreitzer G. SNAREs and epithelial cells. Methods. 2003 ;30:191–197.

Low SH, Li X, Miura M, Kudo N, Quiñones B, Weimbs T. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Developmental Cell. 2003 ;4:753–759.

Kreitzer G, Schmoranzer J, Low SH, Li X, Gan Y, Weimbs T, Simon SM, Rodriguez-Boulan E. Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nature Cell Biology. 2003 ;5:126–136.

Li X, Low SH, Miura M, Weimbs T. SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes. American Journal of Physiology-Renal Physiology. 2002 ;283:F1111–F1122.

Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T. Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Journal of Cell Science. 2002 ;115:4545–4553.

Guangyi Liu, PhD

Present Position: 
Chief Physician, Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China
Years in Lab: 
2015-2016
Publications from Lab: 

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 ;11(8):e0161525.

Sambuddho Mukherjee, PhD

Present Position: 
Associate Director, Biocon Bristol-Myers Squibb Research and Development Center, Bangalore, India
Years in Lab: 
2004-2007
Publications from Lab: 

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2011 ;108:18067–18072.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T. Polycystin-1 regulates STAT activity by a dual mechanism. Proceedings of the National Academy of Sciences. 2011 ;108:7985–7990.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Developmental Cell. 2006 ;10:57–69.

Elena Reales, PhD

Present Position: 
Marie Curie Fellow, Department of Cell Biology, Yale University
Years in Lab: 
2006-2010 (Support: Postdoctoral Fellowship, Spanish Ministry of Education and Science)
Publications from Lab: 

Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018 ;293:5478-5491.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells. Bio-Protocol. 2018 ;8(3):e2453.

Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Mono-ubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes. Mol Biol Cell. 2017 ;28:2843-2853.

Reales E, Sharma N, Low SH, Fölsch H, Weimbs T. Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity. PLOS One. 2011 ;6:e21181.

Mina Rezaei, PhD

Years in Lab: 
2014-17
Awards & Funding: 
Early Mobility Postdoctoral Fellowship, and Advanced Mobility Postdoctoral Fellowship, Swiss National Science Foundation
Publications from Lab: 

Kipp KR, Rezaei M, Lin L, Dewey EC, Weimbs T. A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2016 ;310: F726 –F731.

Olsan EE, Matsushita T, Rezaei M, Weimbs T. Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease. J Biol Chem. 2015 ;290:15679–15686.

Mahmoud Sherief, MD

Present Position: 
Professor, Department of Urology, Suez Canal University Hospital, Ismailia, Egypt
Years in Lab: 
2001-2002 (Support: Fellowship in Urological Research, Egyptian Government)
Publications from Lab: 

Sherief MH, Low SH, Miura M, Kudo N, Novick AC, Weimbs T. Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay. The Journal of Urology. 2003 ;169:1530–1534.

Christine Winterstein, PhD

Present Position: 
Head of Medical Affairs, Merck Group, Oslo, Norway
Years in Lab: 
2007-2012 (Support: Postdoctoral Fellowship, Cancer Center of Santa Barbara)
Publications from Lab: 

Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018 ;293:5478-5491.

Beatrix Wulkersdorfer, MD

Present Position: 
Internal Medicine Residency Program at Department for Clinical Pharmacology, Medical University Vienna
Years in Lab: 
2009-2012
Publications from Lab: 

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2011 ;108:18067–18072.

Zhizhou Zhang, PhD

Present Position: 
Professor, School of Life Science and Biotechnology, Shanghai Jiao Tong University, China
Years in Lab: 
2000-2001

Other Doctoral Level

Ryan Hedgepeth, MD (Cleveland Clinic Urological Institute)

Present Position: 
Chief of Urological Services, OhioHealth Physician Group, Columbus, Ohio
Years in Lab: 
2004-2005
Publications from Lab: 

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2006 ;103:5466–5471.

Constance Marks, MD (Cleveland Clinic Urological Institute)

Present Position: 
Urologist, Advanced Urology Associates, Joliet, IL
Years in Lab: 
2004-2005

Graduate Students

Kevin Kipp, PhD

Present Position: 
Scientist, Bioniz, Irvine, California
Years in Lab: 
2009-2016
Publications from Lab: 

Kipp KR, Kruger SL, Schimmel MF, Parker N, Shillingford JM, Leamon CP, Weimbs T. Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2018 ;315:F395–F405.

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 ;11(8):e0161525.

Kipp KR, Rezaei M, Lin L, Dewey EC, Weimbs T. A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2016 ;310: F726 –F731.

Samantha Kruger, MA

Present Position: 
Medical Student, Drexel University, College of Medicine, PA
Years in Lab: 
2015-18
Publications from Lab: 

Kipp KR, Kruger SL, Schimmel MF, Parker N, Shillingford JM, Leamon CP, Weimbs T. Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2018 ;315:F395–F405.

Weimbs T, Schillingford JM, Torres J, Kruger SL, Bourgeois BC. Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. Clinical Kidney Journal. 2018 ;11(suppl_1):i27–i38.

Allison (Szu Yu) Liu

Present Position: 
Dentistry Student, UCSF
Years in Lab: 
2017-19

Neda Marhamati, B.S.

Eiko Nishiuchi, M.A.

Present Position: 
Technician, Rockefeller University
Years in Lab: 
2008-2010

Erin Olsan, PhD

Present Position: 
Postdoctoral Scholar, UC Davis
Years in Lab: 
2007-2014
Awards & Funding: 
Carbon-Clarke Fellowship (2006); C.A. Storke Fellowship (2007); Shing and Sheng-Yung Chang Fellowship for Research in Biochemistry Molecular Biology (2009)
Publications from Lab: 

Olsan EE, West JD, Torres JA, Doerr N, Weimbs T. Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease. Am J Physiol Renal Physiol. 2018 ;315:F86–F96.

Olsan EE, Matsushita T, Rezaei M, Weimbs T. Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease. J Biol Chem. 2015 ;290:15679–15686.

Weimbs T, Olsan EE, Talbot JJ. Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAK-STAT. 2013 ;2:0–1.

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2011 ;108:18067–18072.

Thomas Samitsch (Management Center Innsbruck, MCI)

Years in Lab: 
2018
Awards & Funding: 
Marshall Plan Scholarship, Austrian Marshall Plan Foundation

Nikunj Sharma, PhD

Present Position: 
Postdoctoral Fellow, Case Western Reserve University
Years in Lab: 
2002-2007 (Support: Predoctoral Fellowship, American Heart Association)
Publications from Lab: 

Soo-Hoo L, Banna CD, Radeke CM, Sharma N, Albertolle ME, Low SH, Weimbs T, Vandenberg CA. The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. PLoS One. 2016 ;11(9):e0163671.

Reales E, Sharma N, Low SH, Fölsch H, Weimbs T. Basolateral sorting of syntaxin 4 is dependent on its N-terminal domain and the AP1B clathrin adaptor, and required for the epithelial cell polarity. PLOS One. 2011 ;6:e21181.

Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Molecular Biology of the Cell. 2006 ;17:977–989.

Sharma N, Low SH, Misra S, Pallavi B, Weimbs T. Apical targeting of syntaxin 3 is essential for epithelial cell polarity. The Journal of Cell Biology. 2006 ;173:937–948.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Developmental Cell. 2006 ;10:57–69.

Jeff Talbot, PhD

Present Position: 
Senior Scientist at Regeneron Pharmaceuticals, Rensselaer, New York
Years in Lab: 
2006-2013
Publications from Lab: 

Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T. The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 2014 ;25(8):1737-48.

Weimbs T, Olsan EE, Talbot JJ. Regulation of STATs by polycystin-1 and their role in polycystic kidney disease. JAK-STAT. 2013 ;2:0–1.

Weimbs T, Talbot JJ. STAT3 signaling in polycystic kidney disease. Drug Discovery Today: Disease Mechanisms. 2013 ;10(3-4):e113-e118.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T. Polycystin-1 regulates STAT activity by a dual mechanism. Proceedings of the National Academy of Sciences. 2011 ;108:7985–7990.

Shivakumar Vasanth, PhD

Present Position: 
Instructor of Ophthalmology, Harvard Medical School, Boston, MA; Study Director, Toxikon Corporation, Bedford, MA
Years in Lab: 
2003-2007
Publications from Lab: 

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T. Polycystin-1 regulates STAT activity by a dual mechanism. Proceedings of the National Academy of Sciences. 2011 ;108:7985–7990.

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Developmental Cell. 2006 ;10:57–69.

Johan Waern, MD PhD

Present Position: 
Internal Medicine Specialist at Sahlgrenska University Hospital, Post-Doctorate; CEO HepGene Medical AB
Years in Lab: 
2004-2006 (Undergraduate research and MS thesis research)

Jonathan West, M.A.

Present Position: 
Medical Student at Keck School of Medicine of the University of Southern California
Years in Lab: 
2015-2017
Publications from Lab: 

Olsan EE, West JD, Torres JA, Doerr N, Weimbs T. Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease. Am J Physiol Renal Physiol. 2018 ;315:F86–F96.

Technical Staff / Work-Study Students

Tammera Davis

Years in Lab: 
2004-2005

Bonnie Gorzelle

Years in Lab: 
2003-2004

Min He

Years in Lab: 
2003-2004

Junko Iwasaki

Years in Lab: 
2002-2004

Tia Jones

Years in Lab: 
2017-19

Michelle Koo

Years in Lab: 
2004-2005
Publications from Lab: 

Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Molecular Biology of the Cell. 2006 ;17:977–989.

Noriko Kudo

Years in Lab: 
2000-2002
Publications from Lab: 

Sherief MH, Low SH, Miura M, Kudo N, Novick AC, Weimbs T. Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay. The Journal of Urology. 2003 ;169:1530–1534.

Low SH, Li X, Miura M, Kudo N, Quiñones B, Weimbs T. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Developmental Cell. 2003 ;4:753–759.

Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T. Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Journal of Cell Science. 2002 ;115:4545–4553.

Claire Larson

Years in Lab: 
2002-2005
Publications from Lab: 

Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Developmental Cell. 2006 ;10:57–69.

Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2006 ;103:5466–5471.

Masumi Miura

Years in Lab: 
1999-2001
Publications from Lab: 

Sherief MH, Low SH, Miura M, Kudo N, Novick AC, Weimbs T. Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay. The Journal of Urology. 2003 ;169:1530–1534.

Low SH, Li X, Miura M, Kudo N, Quiñones B, Weimbs T. Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells. Developmental Cell. 2003 ;4:753–759.

Li X, Low SH, Miura M, Weimbs T. SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes. American Journal of Physiology-Renal Physiology. 2002 ;283:F1111–F1122.

Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T. Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Journal of Cell Science. 2002 ;115:4545–4553.

Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T. Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity. Molecular Biology of the Cell. 2000 ;11:3045–3060.

George Todorov

Present Position: 
Senior Research Associate, Adverum Biotechnologies, Menlo Park, CA
Years in Lab: 
2007-2010
Publications from Lab: 

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2011 ;108:18067–18072.

Interns

Louis Lin, B.S.

Present Position: 
Graduate Student, The University of British Columbia, Pharmaceutical Sciences
Years in Lab: 
2015-2016
Publications from Lab: 

Kipp KR, Rezaei M, Lin L, Dewey EC, Weimbs T. A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2016 ;310: F726 –F731.

Tamami Matsushita, MS

Years in Lab: 
2012-2014
Publications from Lab: 

Olsan EE, Matsushita T, Rezaei M, Weimbs T. Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease. J Biol Chem. 2015 ;290:15679–15686.

Undergraduate Students

Jacob Andrew (MCDB, UCSB)

Years in Lab: 
2016-2017

Laura Andrews

Present Position: 
Co-founder at Azurite Technologies, Inc, San Francisco Bay Area
Years in Lab: 
2011

Miguel Arribas (MCDB, UCSB)

Present Position: 
Medical Student, University of Michigan, Ann Arbor
Years in Lab: 
2009-2012

Mustafa Bahramand (MCDB, UCSB)

Present Position: 
Medical Student at California Northstate University College of Medicine
Years in Lab: 
2012-2013

Jesse Benza (MCDB, UCSB)

Present Position: 
Graduate student, Johns Hopkins University
Years in Lab: 
2014-2016
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Research Grant (2014 and 2015)
Publications from Lab: 

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 ;11(8):e0161525.

Matthew Bliss (MCDB, UCSB)

Present Position: 
M.S. from University of California, Irvine; currently Scientific Associate, Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA
Years in Lab: 
2009-2011

Caroline Broderick (MCDB, UCSB)

Present Position: 
Research Associate, Surrozen, Inc, South San Francisco, CA
Years in Lab: 
2016-2017

Joshua Burgos-Ponce (College of Creative Studies, UCSB)

Years in Lab: 
2017

Abby Camenisch (MCDB, UCSB)

Years in Lab: 
2017

Alyssa Capuano (MCDB, UCSB)

Present Position: 
Graduate Student, UC Davis School of Veterinary Medicine, Davis, California
Years in Lab: 
2006-2009 (Support: Undergraduate Research and Creative Activities grant award (UCSB, Summer 2007) and Stipanich Undergraduate Research Award (Summer 2008))

Alberto Carreno

Present Position: 
PhD graduate student, Biological Sciences, University of California, San Diego
Years in Lab: 
2012-2013

Jonathan Charlu (MCDB, UCSB)

Present Position: 
Medical student, Saint Louis University School of Medicine
Years in Lab: 
2011

Sofia Classon (Lund University, Sweden)

Years in Lab: 
2019

Blaire Consales (MCDB, UCSB)

Years in Lab: 
2016-2017

Elyse Dewey (MCDB, UCSB)

Present Position: 
Research Scientist at University of Washington
Years in Lab: 
2012-2015
Awards & Funding: 
2012, 2013 and 2014, Undergraduate Research and Creative Activities (URCA) Grants
Publications from Lab: 

Kipp KR, Rezaei M, Lin L, Dewey EC, Weimbs T. A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease. Am J Physiol Renal Physiol. 2016 ;310: F726 –F731.

Jeff Doelling

Present Position: 
Medical Student at California Northstate University College of Medicine
Years in Lab: 
2012-2013 (Support: Faculty Research Assistance Program (FRAP) Award, Fall 2012 and Winter 2013)

Linden Doss (College of Creative Studies, UCSB)

Present Position: 
MD from Loma Linda University; currently Resident Physician at Loma Linda University Health
Years in Lab: 
2008-2009

Daniel Durando (MCDB, UCSB)

Present Position: 
Doctor of Physical Therapy (DPT) from University of Alabama at Birmingham; currently Physical Therapist at Focus Physiotherapy, Huntsville, Alabama
Years in Lab: 
2010-2011

Darcey Elliott

Present Position: 
Master’s Degree, Physician Assistant from Baylor College of Medicine, Houston, TX; currently Emergency Medicine Physician Assistant at Barnes-Jewish Hospital, WUSM, Saint Louis, Missouri
Years in Lab: 
2012

Patrick Fann

Present Position: 
Medical student, Case Western Reserve University
Years in Lab: 
2012-2013 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant; 2013 Crowe Family Summer Research Fellowship (UCSB))

Andrea Feldman

Years in Lab: 
2012-2013 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant)

Kathryn Fulton (MCDB, UCSB)

Years in Lab: 
2018-19

Tatiana Getman (MCDB, UCSB)

Present Position: 
Medical Student, Western University of Health Sciences
Years in Lab: 
2014-2016

Alexis Gibson

Years in Lab: 
2011- 2013 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant)

Shaun Goldstone (MCDB, UCSB)

Present Position: 
Director, Strategic Partnerships at American Jewish Joint Distribution Committee (JDC), New York
Years in Lab: 
2008-2010

Nina Heppner

Present Position: 
Medical Student at Ludwig Maximilian University of Munich, Germany
Years in Lab: 
2011-2013 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant)

Deborah Im (MCDB, UCSB)

Present Position: 
Medical Student, Keck School of Medicine, University of Southern California
Years in Lab: 
2015-2017

Daniel Inouye (MCDB, UCSB)

Years in Lab: 
2016-2017

Claudia Jette (MCDB, UCSB)

Present Position: 
PhD graduate student, Biochemistry and Molecular Biophysics, Caltech, Pasadena, CA
Years in Lab: 
2012-2015
Awards & Funding: 
Perlegos Summer Research Fellowship (UCSB, 2013); Undergraduate Research and Creative Activities (URCA) Grant (2013 and 2014)

Eliana Jolkovsky (MCDB, UCSB)

Years in Lab: 
2015

Maddison Kane (MCDB, UCSB)

Present Position: 
Medical Student, Geisinger Commonwealth School of Medicine, PA
Years in Lab: 
2013-2015
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Grant (2014)

Wendy Kerwin (Wenderski) (MCDB, UCSB)

Present Position: 
Research Assistant, The Rockefeller University
Years in Lab: 
2006-2008

Tracey Kiuri (MCDB, UCSB)

Present Position: 
Project Associate at John Snow, Inc., Boston, MA
Years in Lab: 
2014

Susanne Kneringer (Management Center Innsbruck, University of Applied Sciences, Austria)

Years in Lab: 
2011 (Support: The Austrian Marshall Plan Foundation)

Solomiya Kryshtafovych (MCDB, UCSB)

Present Position: 
Medical Student, University of California San Diego
Years in Lab: 
2013-2015
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Grant (2014)

Elizabeth Kuge (MCDB, UCSB)

Years in Lab: 
2013-2014

Kevin Landefeld (MCDB, UCSB)

Present Position: 
Undergraduate Research and Creative Activities grant award (UCSB, Summer 2011)
Years in Lab: 
2010-2011 (Support: Undergraduate Research and Creative Activities grant award (UCSB, Summer 2011))

Robin Laskey (University of Dayton)

Present Position: 
MD from Medical College of Virginia, Virginia Commonwealth University; currently Gynecologic Oncology Specialist, Cleveland Clinic Akron General, Akron, OH
Years in Lab: 
2001-2002 (Support: American Heart Association, Undergraduate Summer Research Fellowship)

Katie Lee (MCDB, UCSB)

Present Position: 
Medical Student at SUNY Downstate College of Medicine
Years in Lab: 
2013-2015
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Grant (2013 and 2014)

Linda Li (MCDB, UCSB)

Present Position: 
Graduate Student, Washington University, St. Louis
Years in Lab: 
2012-2013

Jason Litvinchuk (MCDB, UCSB)

Years in Lab: 
2019

Madelyn Mar (MCDB, UCSB)

Present Position: 
Full Line Associate Territory Manager at Bard Davol
Years in Lab: 
2014-2016
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Grant (2014)

Michael Maser (College of Creative Studies, UCSB)

Present Position: 
PhD Graduate Student, Caltech, Pasadena, CA
Years in Lab: 
2015-2016

Madeline Matthys (Duke University)

Present Position: 
Research Assistant, University of California, San Francisco
Years in Lab: 
2017
Awards & Funding: 
American Physiological Society, Summer Research Fellowship

Elite Mekel (MCDB, UCSB)

Present Position: 
Doctor of Dental Medicine (DMD) from University of Pennsylvania; currently pediatric dentistry practitioner in Encino, CA
Years in Lab: 
2010

Juliana Metichecchia (MCDB, UCSB)

Present Position: 
Associate Researcher at The University of Kansas
Years in Lab: 
2008-2009

Ali Michelotti (MCDB, UCSB)

Years in Lab: 
2015-2016
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Research Grant (2015)

Adam Monahan (College of Creative Studies, UCSB)

Years in Lab: 
2013-14

Sabrina Morales (MCDB, UCSB)

Years in Lab: 
2018-19

Kevin Morse (MCDB, UCSB)

Years in Lab: 
2012

Sirpi Nackeeran (College of Creative Studies, UCSB)

Present Position: 
Medical student, University of Miami Miller School of Medicine
Years in Lab: 
2013-2016
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Research Grant (2013 and 2014)

Jeffrey Patten (MCDB, UCSB)

Present Position: 
Doctor of Dental Surgery (DS) from University of the Pacific; currently at Patten Family Dentistry, Moscow, Idaho
Years in Lab: 
2010-2011

Diana Phan (MCDB, UCSB)

Present Position: 
Graduate Student, Johns Hopkins University/National Human Genome Research Institute
Years in Lab: 
2013-2015 (Support: Regents Scholarship, UCSB)

Jessica Pritt (Zimmerer) (John Carroll University)

Present Position: 
PharmD from Ohio State University, Pharmacist at Mount Carmel Health System, Columbus, Ohio
Years in Lab: 
2004

Kian Rahbari (MCDB, UCSB)

Years in Lab: 
2015-2017
Awards & Funding: 
2015 & 2016 Undergraduate Research and Creative Activities (URCA) Grant

Pasha Rahbari (MCDB, UCSB)

Present Position: 
Medical Student, UCSF School of Medicine
Years in Lab: 
2013-2015
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Grant (2014)

Brandon Rose (MCDB, UCSB)

Present Position: 
Medical Student, University of Miami Miller School of Medicine
Years in Lab: 
2015-2016
Awards & Funding: 
UC LEADS scholar (2014-16); Jeremy D. Friedman Memorial Award (2016)

Vicky Roseman (MCDB, UCSB)

Years in Lab: 
2018

Diane Rusu (MCDB, UCSB)

Present Position: 
Technician/ Research and Development at Celerus Diagnostics, Santa Barbara, California
Years in Lab: 
2012-2013 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant)

Alyssa Sahu (MCDB, UCSB)

Present Position: 
Patient Care Coordinator at Nova IVF, Cupertino, California
Years in Lab: 
2016-18

Joseph Sandoval (College of Creative Studies, UCSB)

Present Position: 
Scientist I at Abbvie Stemcentrx, South San Francisco, CA
Years in Lab: 
2011-2012

Matthew Schefft (Kenyon College)

Present Position: 
MD from Ohio University; currently Assistant Professor of Pediatrics, Children's Hospital of Richmond at VCU
Years in Lab: 
2002

Dawa Sherpa (MCDB, UCSB)

Present Position: 
MD degree from UCSF; currently Resident, Highland Hospital, Oakland CA
Years in Lab: 
2010-2011

Jason Sidrak (MCDB, UCSB)

Years in Lab: 
2018

Tatevik Simavorian (MCDB, UCSB)

Present Position: 
Medical Student at Touro University California, Vallejo, CA
Years in Lab: 
2013-2014

Frances Stedham (University of Cambridge, UK)

Years in Lab: 
2004

Alex Sterritt (MCDB, UCSB)

Years in Lab: 
2017-2018

Lisanne Stouthart (HU University of Applied Sciences Utrecht, The Netherlands)

Years in Lab: 
2018-19

Kiera Sullivan (College of Creative Studies, UCSB)

Years in Lab: 
2018-19

Sammantha Tai (MCDB, UCSB)

Present Position: 
Science Teacher at Downtown College Prep, San Jose, CA
Years in Lab: 
2008-2009

Lydia Truong (MCDB, UCSB)

Present Position: 
Medical student, Uniformed Services University of the Health Sciences
Years in Lab: 
2012-2013 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant)

Elizabeth Usedom (MCDB, UCSB)

Present Position: 
Graduate Student, Drexel University
Years in Lab: 
2008-2009

Chinmay Vaidya (MCDB, UCSB)

Years in Lab: 
2016-19

Meghana Vijayraghavan (MCDB, UCSB)

Present Position: 
Graduate Student, University of San Francisco
Years in Lab: 
2016-2017

Kristina Vucci (MCDB, UCSB)

Years in Lab: 
2016-2017

Elizabeth Vukin (Loh) (John Carroll University)

Present Position: 
Assistant Professor, Pediatrics, University of Utah School of Medicine
Years in Lab: 
2000-2001 (Support: American Heart Association, Undergraduate Summer Research Fellowship)

David Wallace (MCDB, UCSB)

Present Position: 
MD from Keck School of Medicine, University of Southern California; currently Resident Physician at Keck Medicine of USC
Years in Lab: 
2011-2013 (Support: EUREKA undergraduate research internship, Center for Science and Engineering Partnerships (CSEP) at the California Nanosystems Institute (CNSI), UCSB)

Yidi Wang (College of Creative Studies, UCSB)

Present Position: 
Medical Student, Harvard Medical School
Years in Lab: 
2009-2013 (Support:NIH-NIDDK, "Recovery Act Funds for Administrative Supplements Providing Summer Research Experiences for Students and Science Educators” (Summer 2009); American Heart Association, Undergraduate Student Research Fellowship, (Summer 2011))
Publications from Lab: 

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 ;11(8):e0161525.

Emma Wrenn (MCDB, UCSB)

Present Position: 
Graduate Student, University of Washington, Molecular and Cellular Biology Graduate Program
Years in Lab: 
2013-2014
Awards & Funding: 
Undergraduate Research and Creative Activities (URCA) Grant (2013)

Nicole Wypychowski (MCDB, UCSB)

Years in Lab: 
2012 (Support: 2012 Undergraduate Research and Creative Activities (URCA) Grant)

Yuan Xie (MCDB, UCSB)

Years in Lab: 
2017-2018

Mimi Xu (MCDB, UCSB)

Present Position: 
Medical Student, University of Southern California
Years in Lab: 
2013-2016
Publications from Lab: 

Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018 ;293:5478-5491.