Publications

2018

Billot K, Coquil C, Villiers B, Josselin-Foll B, Desban N, Delehouze C, Oumata N, Le Meur Y, Boletta A, Weimbs T, Grosch M, Witzgall R, Saunier S, Fischer E, Pontoglio M, Fautrel A, Mrug M, Wallace DPaul, Tran PV, Trudel M, Bukanov NO, Ibraghimov-Beskrovnaya O, Meijer L. Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. Am J Physiol Renal Physiol. 2018 ;315:F57–F73.
Giovannone AJ, Winterstein C, Bhattaram P, Reales E, Low SH, Baggs JE, Xu M, Lalli MA, Hogenesch JB, Weimbs T. Soluble syntaxin 3 functions as a transcriptional regulator. J Biol Chem. 2018 ;293:5478-5491.
Weimbs T, Schillingford JM, Torres J, Kruger SL, Bourgeois BC. Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease. Clinical Kidney Journal. 2018 ;11(suppl_1):i27–i38.
Giovannone AJ, Reales E, Bhattaram P, Fraile-Ramos A, Weimbs T. Tracking Endocytosis and Intracellular Trafficking of Epitope-tagged Syntaxin 3 by Antibody Feeding in Live, Polarized MDCK Cells. Bio-Protocol. 2018 ;8(3):e2453.

2016

Soo-Hoo L, Banna CD, Radeke CM, Sharma N, Albertolle ME, Low SH, Weimbs T, Vandenberg CA. The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. PLoS One. 2016 ;11(9):e0163671.
Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS One. 2016 ;11(8):e0161525.

2015

Rothé B, Leal-Esteban L, Bernet F, Urfer S, Doerr N, Weimbs T, Iwaszkiewicz J, Constam DB. Bicc1 polymerization regulates the localization and silencing of bound mRNA. Mol Cell Biol. 2015 ;35:3339-3353.

2014

Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T. The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol. 2014 ;25(8):1737-48.

2013

Weimbs T, Talbot JJ. STAT3 signaling in polycystic kidney disease. Drug Discovery Today: Disease Mechanisms. 2013 ;10(3-4):e113-e118.

2011

Olsan EE, Mukherjee S, Wulkersdorfer B, Shillingford JM, Giovannone AJ, Todorov G, Song X, Pei Y, Weimbs T. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proceedings of the National Academy of Sciences. 2011 ;108:18067–18072.
Weimbs T. Third-hit signaling in renal cyst formation. Journal of the American Society of Nephrology. 2011 ;22:793–795.

2010

Torres VE, Boletta A, Chapman A, Gattone V, Pei Y, Qian Q, Wallace DP, Weimbs T, Wüthrich RP. Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases. Clinical Journal of the American Society of Nephrology. 2010 ;5:1312–1329.
Shillingford JM, Piontek KB, Germino GG, Weimbs T. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. Journal of the American Society of Nephrology. 2010 ;21:489–497.

2009

Mistry AC, Mallick R, Klein JD, Weimbs T, Sands JM, Fröhlich O. Syntaxin specificity of aquaporins in the inner medullary collecting duct. American Journal of Physiology-Renal Physiology. 2009 ;297:F292–F300.

2007

Weimbs T. Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1. American Journal of Physiology-Renal Physiology. 2007 ;293:F1423–F1432.
Dai S, Zhang Y, Weimbs T, Yaffe MB, Zhou D. Bacteria-generated PtdIns (3) P Recruits VAMP8 to Facilitate Phagocytosis. Traffic. 2007 ;8:1365–1374.

2006

Kidd GJ, Yadav VK, Huang P, Brand SL, Low SH, Weimbs T, Trapp BD. A dual tyrosine-leucine motif mediates myelin protein P0 targeting in MDCK cells. Glia. 2006 ;54:135–145.
Sharma N, Low SH, Misra S, Pallavi B, Weimbs T. Apical targeting of syntaxin 3 is essential for epithelial cell polarity. The Journal of Cell Biology. 2006 ;173:937–948.

2005

Fei B, Flask C, Wang H, Pi A, Wilson DL, Shillingford J, Murcia N, Weimbs T, Duerk JL. Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice. Conf Proc IEEE Eng Med Biol Soc. . 2005 :467–469.

2004

Fan S, Hurd TW, Liu C-J, Straight SW, Weimbs T, Hurd EA, Domino SE, Margolis B. Polarity proteins control ciliogenesis via kinesin motor interactions. Current Biology. 2004 ;14:1451–1461.
Tartakoff AM, A Matera G, Pimplikar SW, Weimbs T. Regulation of nuclear functions–nucleocytoplasmic transport in context. European Journal of Cell Biology. 2004 ;83:185–192.

2003

Kreitzer G, Schmoranzer J, Low SH, Li X, Gan Y, Weimbs T, Simon SM, Rodriguez-Boulan E. Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nature Cell Biology. 2003 ;5:126–136.
Weimbs T, Low SH, Li X, Kreitzer G. SNAREs and epithelial cells. Methods. 2003 ;30:191–197.

2002

Li X, Low SH, Miura M, Weimbs T. SNARE expression and localization in renal epithelial cells suggest mechanism for variability of trafficking phenotypes. American Journal of Physiology-Renal Physiology. 2002 ;283:F1111–F1122.
Low SH, Marmorstein LY, Miura M, Li X, Kudo N, Marmorstein AD, Weimbs T. Retinal pigment epithelial cells exhibit unique expression and localization of plasma membrane syntaxins which may contribute to their trafficking phenotype. Journal of Cell Science. 2002 ;115:4545–4553.
van Ijzendoorn SCD, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Developmental Cell. 2002 ;2:219–228.

2001

Lim S-N, Bonzelius F, Low SH, Wille H, Weimbs T, Herman GA. Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins. Molecular Biology of the Cell. 2001 ;12:981–995.

2000

Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T. Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity. Molecular Biology of the Cell. 2000 ;11:3045–3060.

1998

Low SH, Roche PA, Anderson HA, van Ijzendoorn SCD, Zhang M, Mostov KE, Weimbs T. Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. Journal of Biological Chemistry. 1998 ;273:3422–3430.
Low SH, Chapin SJ, Wimmer C, Whiteheart SW, Kömüves LG, Mostov KE, Weimbs T. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. The Journal of Cell Biology. 1998 ;141:1503–1513.

1997

Weimbs T, Low SH, Chapin SJ, Mostov KE, Bucher P, Hofmann K. A conserved domain is present in different families of vesicular fusion proteins: a new superfamily. Proceedings of the National Academy of Sciences. 1997 ;94:3046–3051.

1996

Low SH, Chapin SJ, Weimbs T, Kömüves LG, Bennett MK, Mostov KE. Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells. Molecular Biology of the Cell. 1996 ;7:2007-2018.

1995

Mostov KE, Altschuler Y, Chapin SJ, Enrich C, Low SH, Luton F, Richman-Eisenstat J, Singer KL, Tang K, Weimbs T. Regulation of protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor model. Cold Spring Harbor Symposia on Quantitative Biology. 1995 ;60:775–781.

1990

Weimbs T, DICK T, Stoffel W, BOLTSHAUSER E. A point mutation at the X-chromosomal proteolipid protein locus in Pelizaeus-Merzbacher disease leads to disruption of myelinogenesis. Biological Chemistry Hoppe-Seyler. 1990 ;371:1175–1184.