News

New review article published explaining how polycystic kidney disease progression is not just driven by genetics but by nutrition and lifestyle triggers

October 31, 2024

Messing, Melina, Jacob A. Torres, Nickolas Holznecht, and Thomas Weimbs. “Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression.” Nutrients 16, no. 19 (January 2024): 3281.

https://doi.org/10.3390/nu16193281

 

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New paper published in iScience

September 27, 2024

Congratulations to all authors!

Torres, J. A.; Holznecht, N.; Asplund, D. A.; Kroes, B. C.; Amarlkhagva, T.; Haeffner, M. M.; Sharpe, E. H.; Koestner, S.; Strubl, S.; Schimmel, M. F.; Kruger, S.; Agrawal, S.; Aceves, B. A.; Thangaraju, M.; Weimbs, T. β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease. iScience 2024, 27 (9). https://doi.org/10.1016/j.isci.2024.110773.

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New review article published titled "The case for a ketogenic diet in the management of kidney disease"

April 29, 2024

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Latest paper published: "A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a 3 Rat Model of Polycystic Kidney Disease"

December 14, 2023

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Results of the KETO-ADPKD clinical trial published

November 16, 2023

The first randomized controlled trial on ketogenic metabolic therapy in polycystic kidney disease

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Hannah Pellegrini awarded PhD degree

September 20, 2023

Congratulations to DOCTOR Hannah Pellegrini for successfully defending her dissertation and becoming a PhD !!
Hannah's dissertation title is "Role and Regulation of C-terminal Cleavage Fragments of Polycystin-1" and her work was recently published as a first-authored paper in the Journal of Biological Chemistry.
Photos the kidney cake (before/after) attached. Nobody ever eats the ureter!
KetoCitra cocktails were a hit thanks to former star bar mixer Dr. Jacob Torres.

 

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Latest paper from Weimbs Lab published in the Journal of Biological Chemistry

August 15, 2023

Pellegrini H, Sharpe EH, Liu G, Nishiuchi E, Doerr N, Kipp KR, Chin T, Schimmel MF, Weimbs T. Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction. J Biol Chem. 2023 :105158 (Online ahead of print)

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Weimbs Lab featured in UC Santa Barbara Magazine

June 20, 2023

Breaking Through: Advancing medicine by way of research

UC Santa Barbara Magazine, Spring/Summer 2023

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UC Santa Barbara Magazine

URCA grants awarded to six undergrads in lab

January 28, 2023

Congratulations to the following undergraduate students in the Weimbs lab for being awarded URCA (Undergraduate Research & Creative Activities) grants for their research projects on polycystic kidney disease in the lab: Thomas Evans, Kareena Johnson, Reece Foehr, Cynthia Dharmawan, Sage Patel, Deeyana Roshanzear

New paper just published: "RESET-PKD: A pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease"

November 25, 2022

RESET-PKD: A pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney disease 

Simon Oehm, Konstantin Steinke, Johannes Schmidt, Sita Arjune, Polina Todorova, Christoph Lindemann, Fabian Wöstmann, Franziska Meyer, Florian Siedek, Thomas Weimbs,  Roman-Ulrich Müller, Franziska Grundmann

 

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Background

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