News release about our study on developing a new class of monoclonal antibody drugs for polycystic kidney disease therapy. These dimeric-IgA class antibodies have the ability to target to cyst lumens in PKD.
A ‘magic bullet’ for polycystic kidney disease in the making
Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the kidneys. Over time, the painful, growing cysts rob the organs of their function, often leading to dialysis in advanced cases There is currently no cure.
'High-protein diets hurt your kidneys!'. 'Once kidney disease starts, it only gets worse'. Heard something similar? It's just not the whole picture and also showing to be quite far from the truth.
Colgan, D. D.; Stadler, D. D.; Hope, A. A.; Zwickey, H.; Davenport, T. E.; Weimbs, T. Clinically Meaningful Improvements in Long COVID Symptoms Following Ketogenic Metabolic Therapy Combined with Lifestyle Interventions - A Clinical Case Report and Review of the Literature. CRCM 2025, 14 (08), 391–410.
Congratulations to Melina Messing, PhD for receiving the 2025 Jared J. Grantham Research Fellowship Award to support her research in the Weimbs laboratory. Melina will study "Immune Mechanisms Underlying Efficacy of Ketogenic Metabolic Therapy in Polycystic Kidney Disease".
Athinarayanan, S. J.; Roberts, C. G. P.; Phinney, S. D.; Weimbs, T.; Friedman, A. N.; Volek, J. S. Effects of a Continuous Remote Care Intervention Including Nutritional Ketosis on Kidney Function and Inflammation in Adults with Type 2 Diabetes: A Post-Hoc Latent Class Trajectory Analysis. Front. Nutr. 2025, 12. https://doi.org/10.3389/fnut.2025.1609737.
Congratulations to Weimbs Lab undergraduate researcher Emily Ngo who has been accepted to the University of California Leadership Excellence through Advanced Degrees (UC LEADS) program for the 2025-27 Scholar Cohort
Messing, Melina, Jacob A. Torres, Nickolas Holznecht, and Thomas Weimbs. “Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression.” Nutrients 16, no. 19 (January 2024): 3281.
