Thomas Weimbs, PhD
- Ph.D., University of Cologne, Germany, 1993
Publications from Lab
Dr. Weimbs received his doctoral degree from the Department of Biochemistry of the University of Cologne, Germany, in 1993. He conducted postdoctoral research at the Department of Anatomy, University of California at San Francisco until 1999. In the same year, he joined the Department of Cell Biology in the Lerner Research Institute of the Cleveland Clinic as an Assistant Professor where he established his research laboratory focusing on investigating membrane trafficking and epithelial cell polarity as well as molecular mechanisms underlying polycystic kidney disease. In 2005, Dr. Weimbs was recruited to the Department of Molecular, Cellular, and Developmental Biology and moved his laboratory to UCSB. Dr. Weimbs is currently a Professor in the Department of Molecular, Cellular, and Developmental Biology and in the Neuroscience Research Institute.
Research in my laboratory is divided in two interrelated areas of interest. One area is the investigation of molecular mechanisms underlying polycystic kidney disease (PKD) with an emphasis towards identifying therapies. The other area is the investigation of novel functions of SNARE membrane fusion proteins and their role in membrane trafficking and epithelial cell polarity. There has been an amazing level of cross-fertilization between these areas in my lab. With regard to PKD research, my lab is investigating the function of polycystin-1 (PC1), the protein affected in most cases of PKD. In particular, we wish to understand how (and why) PC1 regulates various signaling pathways and how disruption leads to renal cyst growth. In addition, we are identifying novel therapeutic approaches and investigate novel methods to deliver therapeutics to polycystic kidneys.