Publications

Found 25 results
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Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BDavid.  2007.  XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.. Mol Cell. 27(1):53-66.
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Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M et al..  2015.  Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.. Mol Cancer Ther. 14(3):642-8.
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Karagöz GElif, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P.  2017.  An unfolded protein-induced conformational switch activates mammalian IRE1.. Elife. 6
G Karagöz E, Acosta-Alvear D, Walter P.  2019.  The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.. Cold Spring Harb Perspect Biol.
Acosta-Alvear D, Karagöz GElif, Fröhlich F, Li H, Walther TC, Walter P.  2018.  The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1.. Elife. 7
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Tsikitis M, Acosta-Alvear D, Blais A, Campos EI, Lane WS, Sánchez I, Dynlacht BD.  2010.  Traf7, a MyoD1 transcriptional target, regulates nuclear factor-κB activity during myogenesis.. EMBO Rep. 11(12):969-76.
Tufanli O, Akillilar PTelkoparan, Acosta-Alvear D, Kocaturk B, Onat UInci, Hamid SMuhammad, Çimen I, Walter P, Weber C, Erbay E.  2017.  Targeting IRE1 with small molecules counteracts progression of atherosclerosis.. Proc Natl Acad Sci U S A.
S
Rauch JN, Valois E, Solley SC, Braig F, Lach RS, Audouard M, Ponce-Rojas JCarlos, Costello MS, Baxter NJ, Kosik KS et al..  2021.  A Scalable, Easy-to-Deploy, Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material.. J Clin Microbiol.
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Blais A, van Oevelen CJC, Margueron R, Acosta-Alvear D, Dynlacht BDavid.  2007.  Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit.. J Cell Biol. 179(7):1399-412.
G Karagöz E, Aragón T, Acosta-Alvear D.  2019.  Recent advances in signal integration mechanisms in the unfolded protein response.. F1000Res. 8
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Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK-H, Wilson C et al..  2013.  Pharmacological brake-release of mRNA translation enhances cognitive memory.. Elife. 2:e00498.
Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I et al..  2015.  Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.. Elife. 4:e08153.
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Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A.  2014.  Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.. Science. 345(6192):98-101.
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Blais A, Tsikitis M, Acosta-Alvear D, Sharan R, Kluger Y, Dynlacht BDavid.  2005.  An initial blueprint for myogenic differentiation.. Genes Dev. 19(5):553-69.
Armengaud J, Delaunay-Moisan A, Thuret J-Y, van Anken E, Acosta-Alvear D, Aragón T, Arias C, Blondel M, Braakman I, Collet J-F et al..  2020.  The Importance Of Naturally Attenuated Sars-Cov-2 In The Fight Against Covid-19.. Environ Microbiol.
Ibanez A, Santamaria-Garcia H, Barragan AGuerrero, Kornhuber A, Ton AMendonca M, Slachevsky A, Teixeira ALucio, Meza BMarcela Ma, Serrano CM, Cano C et al..  2020.  The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response.. Alzheimers Dement (N Y). 6(1):e12092.
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Dufey E, San Pedro JManuel Bra, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y et al..  2020.  Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.. Nat Commun. 11(1):2401.
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Ponce-Rojas JCarlos, Costello MS, Proctor DA, Kosik KS, Wilson MZ, Arias C, Acosta-Alvear D.  2020.  A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein to Facilitate the Detection of SARS-CoV-2.. J Clin Microbiol.
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Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV et al..  2015.  Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.. Elife. 4
Asp P, Acosta-Alvear D, Tsikitis M, van Oevelen C, Dynlacht BDavid.  2009.  E2f3b plays an essential role in myogenic differentiation through isoform-specific gene regulation.. Genes Dev. 23(1):37-53.
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Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-CAriel, Qing J, Totpal K, Kan D et al..  2019.  Disruption of IRE1α through its kinase domain attenuates multiple myeloma.. Proc Natl Acad Sci U S A.
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Rauch JN, Valois E, Ponce-Rojas JCarlos, Aralis Z, Lach RL, Zappa F, Audouard M, Solley SC, Vaidya C, Costello M et al..  2020.  CRISPR-based and RT-qPCR surveillance of SARS-CoV-2 in asymptomatic individuals uncovers a shift in viral prevalence among a university population. medRxiv.
Peschek J, Acosta-Alvear D, Mendez AS, Walter P.  2015.  A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing.. EMBO Rep. 16(12):1688-98.
Behrman S, Acosta-Alvear D, Walter P.  2011.  A CHOP-regulated microRNA controls rhodopsin expression.. J Cell Biol. 192(6):919-27.
A
Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA et al..  2016.  Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.. J Clin Invest.